Preoperative prediction of peritoneal metastasis in gastric cancer as an indicator for neoadjuvant treatment.

Abstract

AIM:

The aim of the present study was to investigate whether serum markers and clinical factors could be used for preoperative prediction of peritoneal metastasis in gastric cancer (GC) as an indicator for neoadjuvant treatment.

PATIENTS AND METHODS:

We enrolled 493 patients with GC for whom preoperative serum tumor markers [carcinoembryonic antigen (CEA) and carbohydrate antigen (CA)19-9], systemic inflammatory marker C-reactive protein (CRP), host immune markers [neutrophil and lymphocyte counts and their ratio (NLR)], albumin as a nutritional marker, and objective preoperative clinical factors were available as indicators of postoperative peritoneal metastasis.

RESULTS:

Specific clinical factors, including tumor size, histopathology of biopsy sample, and tumor morphology, were significantly correlated with peritoneal metastasis. CA19-9, lymphocyte count and NLR were also predictive factors for peritoneal metastasis. Multivariate analysis identified the clinical factors tumor morphology and histopathology, and laboratory markers CA19-9 and lymphocyte count as independent factors predictive for peritoneal metastasis. A combination of independent predictive factors achieved high predictive accuracy (0.882) for peritoneal metastasis preoperatively.

CONCLUSION:

A combination of specific factors is an alternative method to preoperatively discriminate patients with GC with peritoneal metastasis from those without.

• Authors: Masaki Ohi, Koichiro Mori, Yuji Toiyama, Yasuhiko Mohri, Masato Okigami, Hiromi Yasuda, Susumu Saigusa, Koji Tanaka, Yasuhiro Inoue, Masato Kusunoki
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 6 Pg. 3511-8 (Jun 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26026118 (Publication Type: Journal Article)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• CA-19-9 Antigen
• Carcinoembryonic Antigen
• Serum Albumin
• C-Reactive Protein

Topics

• Adult
• Aged
• Biomarkers, Tumor (blood)
• C-Reactive Protein (metabolism)
• CA-19-9 Antigen (blood)
• Carcinoembryonic Antigen (blood)
• Female
• Humans
• Lymphocyte Count
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Metastasis
• Peritoneal Neoplasms (blood, pathology, secondary)
• Preoperative Period
• Prognosis
• Serum Albumin (genetics)
• Stomach Neoplasms (blood, drug therapy, pathology)