Perspectives On Membrane-associated Progesterone Receptors As Prospective Therapeutic Targets.

Abstract

Progesterone receptor membrane components 1 and 2, neudesin, and neuferricin belong to the membraneassociated progesterone receptor (MAPR) family. Recently, sex steroid membrane receptors have gained attention because of their potential involvement in sex hormone-mediated rapid non-genomic effects, which cannot currently be explained by the genomic action of nuclear receptors. Progesterone may increase cell proliferation and survival via nongenomic effects including the activation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3- kinase (PI3K) pathways through MAPRs. Moreover, the unique expression of MAPRs suggests that they could be used as biomarkers and drug targets for sex steroid-related cancers and other diseases. In this review, we summarize the physiological roles of the MAPRs, provide a comprehensive overview of their progesterone-mediated non-genomic actions, and discuss new insights into their potential as therapeutic targets.

• Authors: Sae Hasegawa, Mayu Kasubuchi, Kazuya Terasawa, Ikuo Kimura
• Journal: Current drug targets (Curr Drug Targets) Vol. 17 Issue 10 Pg. 1189-97 ( 2016) ISSN: 1873-5592 [Electronic] United Arab Emirates
• PMID: 25981602 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)

Chemical References

• Gonadal Steroid Hormones
• Receptors, Progesterone
• Progesterone
• Phosphatidylinositol 3-Kinases
• Mitogen-Activated Protein Kinases

Topics

• Animals
• Cell Proliferation (physiology)
• Drug Design
• Gonadal Steroid Hormones (metabolism)
• Humans
• Mitogen-Activated Protein Kinases (metabolism)
• Molecular Targeted Therapy
• Neoplasms (drug therapy, pathology)
• Phosphatidylinositol 3-Kinases (metabolism)
• Progesterone (metabolism)
• Receptors, Progesterone (metabolism)