Targeted delivery of 5-aminolevulinic acid by multifunctional hollow mesoporous silica nanoparticles for photodynamic skin cancer therapy.

Abstract

5-Aminolevulinic acid (5-ALA) is a precursor of a strong photosensitizer, protoporphyrin IX (PphIX), for photodynamic therapy (PDT). Developing appropriate delivery carriers that can assist 5-ALA in bypassing the lipophilic barrier to directly enter into cancer cells is a research focus. The improved delivery of 5-ALA is even important for skin cancer therapy through PDT process. In this work, targeting ligand folic acid (FA)-functionalized hollow mesoporous silica nanoparticles (HMSNPs) were fabricated to deliver 5-ALA for PDT against B16F10 skin cancer cells. The FA targeting ligand enabled selective endocytosis of 5-ALA loaded HMSNPs into cancer cells. PphIX formed from delivered 5-ALA exhibited high photocytotoxicity to the cancer cells in vitro.

• Authors: Xing Ma, Qiuyu Qu, Yanli Zhao
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 7 Issue 20 Pg. 10671-6 (May 27 2015) ISSN: 1944-8252 [Electronic] United States
• PMID: 25974979 (Publication Type: Letter, Research Support, Non-U.S. Gov't)

Chemical References

• Nanocapsules
• Photosensitizing Agents
• Silicon Dioxide
• Aminolevulinic Acid

Topics

• Aminolevulinic Acid (administration & dosage, chemistry)
• Animals
• Cell Line, Tumor
• Cell Survival (drug effects, radiation effects)
• Diffusion
• Mice
• Nanocapsules (administration & dosage, chemistry, ultrastructure)
• Nanopores (ultrastructure)
• Particle Size
• Photochemotherapy (methods)
• Photosensitizing Agents (administration & dosage, chemistry)
• Porosity
• Silicon Dioxide (chemistry)
• Skin Neoplasms (drug therapy, pathology)
• Treatment Outcome