Abstract | BACKGROUND: METHODS: The effects of oral treatment with 2'-fucosyllactose and 6'-sialyllactose on anaphylactic symptoms induced by oral ovalbumin (OVA) challenge in sensitized mice were investigated. Mast cell functions in response to oral HMO treatment were also measured in the passive cutaneous anaphylaxis model, and direct effects on IgE-mediated degranulation of mast cells were assessed. RESULTS: CONCLUSIONS:
|
Authors | L Castillo-Courtade, S Han, S Lee, F M Mian, R Buck, P Forsythe |
Journal | Allergy
(Allergy)
Vol. 70
Issue 9
Pg. 1091-102
(Sep 2015)
ISSN: 1398-9995 [Electronic] Denmark |
PMID | 25966668
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Allergens
- Oligosaccharides
- Immunoglobulin E
|
Topics |
- Allergens
(immunology)
- Animals
- Cell Count
- Desensitization, Immunologic
- Disease Models, Animal
- Food Hypersensitivity
(diagnosis, immunology, therapy)
- Humans
- Immunoglobulin E
(immunology)
- Immunomodulation
- Intestinal Mucosa
(metabolism)
- Intestines
(cytology, immunology)
- Male
- Mast Cells
(immunology, metabolism)
- Mice
- Milk, Human
(immunology)
- Oligosaccharides
(administration & dosage, immunology)
- T-Lymphocyte Subsets
(immunology, metabolism)
|