Single dose intravenous methyl prednisolone versus oral prednisolone in Bell's palsy: a randomized controlled trial.

Abstract

OBJECTIVES:

Corticosteroids have been used in the treatment of Bell's palsy and several other postinfectious neurological conditions. We hypothesized that administration of a single dose of intravenous (IV) methylprednisolone might be an effective alternative to oral prednisolone.

MATERIALS AND METHODS:

In this open label, randomized trial, patients with acute Bell's palsy were randomized into two groups. One group received single dose (500 mg) of IV methylprednisolone while the other group received 10 days of oral prednisone. Outcome was assessed at 1 and 3 months with House-Brackmann scale.

RESULTS:

At 3 months, 93 (79.48%) patients had completely recovered. IV methylprednisolone and oral prednisolone groups had similar recovery rates (80% vs. 78.33%, P > 0.05). Patients with Grade 2 and 3 recovered completely. In patients with Grade 6, the recovery rate was 20%. A better outcome was observed if corticosteroids were administered within 3 days of onset of palsy.

CONCLUSION:

Intravenous methylprednisolone and oral prednisolone showed equivalent benefit in patients with acute Bell's palsy.

• Authors: Prithvi Giri, Ravindra Kumar Garg, Maneesh Kumar Singh, Rajesh Verma, Hardeep Singh Malhotra, Praveen Kumar Sharma
• Journal: Indian journal of pharmacology (Indian J Pharmacol) 2015 Mar-Apr Vol. 47 Issue 2 Pg. 143-7 ISSN: 1998-3751 [Electronic] India
• PMID: 25878371 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Glucocorticoids
• Prednisone
• Methylprednisolone

Topics

• Acute Disease
• Administration, Oral
• Adult
• Bell Palsy (drug therapy)
• Drug Administration Schedule
• Female
• Glucocorticoids (administration & dosage, therapeutic use)
• Humans
• Injections, Intravenous
• Male
• Methylprednisolone (administration & dosage, therapeutic use)
• Prednisone (administration & dosage, therapeutic use)
• Treatment Outcome