Abstract | OBJECTIVE: METHODS: Bacterial cystitis was induced in Wistar female rats by intravesical inoculation of E. coli. Isotonic saline was instilled in the control group (n = 6). The rats were either non-treated, treated with gentamycin (4 mg/kg, 5 days) or treated intravesically with hyaluronic acid (0.5 mL, 0.5%). On the eighth day, the bladder tissues were excised for histological examination, and the measurements of myeloperoxidase, superoxide dismutase and catalase activities. Contraction/relaxation responses to carbachol, isoprotrenol and papaverine were studied. RESULTS: CONCLUSION:
Gentamycin treatment, despite its ameliorative effect on inflammation, had no impact on the contractile dysfunction of the injured bladder. Intravesical hyaluronic acid, in addition to its supportive role in the healing of the epithelium, seems to lower the increased threshold for contraction and to reduce oxidative stress. These findings support a potential role for hyaluronic acid in the treatment of bacterial cystitis.
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Authors | Nurdan Yıldız, Harika Alpay, Halil Tuğtepe, Zarife Nigar Özdemir Kumral, Dilek Akakın, Arzu İlki, Göksel Şener, Berrak Ç Yeğen |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 22
Issue 6
Pg. 598-603
(Jun 2015)
ISSN: 1442-2042 [Electronic] Australia |
PMID | 25808602
(Publication Type: Journal Article)
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Copyright | © 2015 The Japanese Urological Association. |
Chemical References |
- Adjuvants, Immunologic
- Anti-Bacterial Agents
- Urological Agents
- Hyaluronic Acid
- Catalase
- Peroxidase
- Superoxide Dismutase
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Topics |
- Adjuvants, Immunologic
(administration & dosage)
- Administration, Intravesical
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Catalase
(metabolism)
- Cystitis
(drug therapy, enzymology, microbiology, pathology)
- Escherichia coli
- Escherichia coli Infections
(complications, drug therapy)
- Female
- Hyaluronic Acid
(administration & dosage)
- Muscle Contraction
(drug effects)
- Muscle Relaxation
(drug effects)
- Peroxidase
(metabolism)
- Rats
- Rats, Wistar
- Superoxide Dismutase
(metabolism)
- Urinary Bladder
(drug effects, enzymology)
- Urological Agents
(pharmacology)
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