Abstract | PURPOSE: METHODS: RESULTS: The results showed that positive expression of IMP3 and IGF2 was tightly related to the tumor extension and local recurrence of GCT (P < 0.05), but it did not indicate any association with patients' age, gender, tumor location and size. The mean microvessel densities (MVDs) of IMP3 and IGF2 were significantly higher in positive group than negative group (P < 0.05). Moreover, a significant correlation was found between IMP3 and IGF2 expression (r = 0.355, P = 0.029). The log-rank test revealed that local recurrence-free survival time was significantly shorter in the IMP3 positive group (P = 0.004), and the difference in the IGF2 positive group and negative group was also statistically significant (P = 0.008). CONCLUSION:
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Authors | K Zhang, M Zhou, H Chen, G Wu, K Chen, H Yang |
Journal | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
(Clin Transl Oncol)
Vol. 17
Issue 7
Pg. 570-5
(Jul 2015)
ISSN: 1699-3055 [Electronic] Italy |
PMID | 25740666
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD
- ENG protein, human
- Endoglin
- IGF2 protein, human
- IGF2BP3 protein, human
- RNA-Binding Proteins
- Receptors, Cell Surface
- Insulin-Like Growth Factor II
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Topics |
- Adolescent
- Adult
- Antigens, CD
(metabolism)
- Child
- Endoglin
- Female
- Giant Cell Tumor of Bone
(metabolism, pathology)
- Humans
- Immunohistochemistry
- Insulin-Like Growth Factor II
(metabolism)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(metabolism, pathology)
- Neovascularization, Pathologic
(metabolism, pathology)
- Prognosis
- RNA-Binding Proteins
(metabolism)
- Receptors, Cell Surface
(metabolism)
- Spinal Neoplasms
(metabolism, pathology)
- Young Adult
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