Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells†Electronic supplementary information (ESI) available: Chemicals and reagents, detailed experimental procedures for materials synthesis, characterization, cellular evaluations and supporting figures and tables. See DOI: 10.1039/c4tb01633eClick here for additional data file.

Abstract

Self-assembled micelles of amphiphilic PEG-rapamycin conjugates loaded with paclitaxel have been developed for co-delivery and simultaneous intracellular release of paclitaxel and rapamycin, bypassing the cancer cell drug resistant mechanism and maximising the synergy of dual-drug combinational therapy. This novel nanomedicine offers 20-fold improved potency over free paclitaxel against a model multidrug resistant human breast cancer cell.

• Authors: Wei Tian, Jieying Liu, Yuan Guo, Yuanyuan Shen, Dejian Zhou, Shengrong Guo
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 3 Issue 7 Pg. 1204-1207 (Feb 21 2015) ISSN: 2050-750X [Print] England
• PMID: 25717377 (Publication Type: Journal Article)