Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients.

Abstract

BACKGROUND:

The three branched amino acids (valine, leucine, and isoleucine) and two aromatic amino acids (tyrosine and phenylalanine) have been associated with many adverse metabolic pathways, including diabetes. However, these associations have been identified primarily in otherwise healthy Caucasian populations. We aimed to investigate the association of this five-amino-acid signature with metabolic syndrome and impaired fasting glucose (IFG) in a hypertensive cohort of Caucasian and African Americans.

METHODS:

We analyzed data from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies PEAR and PEAR2 conducted between 2005 and 2014. Subjects were enrolled at the University of Florida (Gainesville, FL), Emory University (Atlanta, GA), and Mayo Clinic (Rochester, MN). A total of 898 patients with essential hypertension were included in this study. Presence of metabolic syndrome and IFG at baseline were determined on the basis of measurements of demographic and biochemical data. Levels of the five amino acids were quantified by liquid chromatography-tandem mass spectroscopy (LC-MS/MS).

RESULTS:

With a multiple logistic regression model, we found that all five amino acids were significantly associated with metabolic syndrome in both Caucasian and African Americans. IFG and the five amino acids were associated in the Caucasian Americans. Only valine was significantly associated with IFG in African Americans.

CONCLUSION:

In both Caucasian and African Americans with uncomplicated hypertension, plasma levels of the five-amino-acid signature are associated with metabolic syndrome. Additionally, in Caucasians we have confirmed the five-amino-acid signature was associated with IFG.

• Authors: Liming Weng, Eoin Quinlivan, Yan Gong, Amber L Beitelshees, Mohamed H Shahin, Stephen T Turner, Arlene B Chapman, John G Gums, Julie A Johnson, Reginald F Frye, Timothy J Garrett, Rhonda M Cooper-DeHoff
• Journal: Metabolic syndrome and related disorders (Metab Syndr Relat Disord) Vol. 13 Issue 5 Pg. 195-202 (Jun 2015) ISSN: 1557-8518 [Electronic] United States
• PMID: 25664967 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)

Chemical References

• Amino Acids, Aromatic
• Amino Acids, Branched-Chain
• Antihypertensive Agents
• Blood Glucose

Topics

• Adolescent
• Adult
• Black or African American
• Aged
• Amino Acids, Aromatic (blood)
• Amino Acids, Branched-Chain (blood)
• Antihypertensive Agents (therapeutic use)
• Blood Glucose (analysis)
• Chromatography, Liquid
• Cohort Studies
• Essential Hypertension
• Fasting
• Female
• Humans
• Hypertension (blood, complications, genetics)
• Logistic Models
• Male
• Mass Spectrometry
• Metabolic Syndrome (blood, complications, ethnology, genetics)
• Middle Aged
• Pharmacogenetics
• United States
• White People
• Young Adult