Colloidal oatmeal formulations and the treatment of atopic dermatitis.

Abstract

Colloidal oatmeal suspensions are currently available in bath soaps, shampoos, shaving gels, and moisturizing creams, and several studies have been conducted that demonstrate the efficacy and safety of colloidal oatmeal for the treatment of inflammatory skin conditions. The diverse chemical polymorphism of oats translates into numerous clinical utilities for atopic dermatitis (AD) and eczema. Avenanthramides are the principle polyphenolic antioxidants in oats, and they have been shown to assuage inflammation in murine models of contact hypersensitivity and neurogenic inflammation and also reduce pruritogen-induced scratching in a murine itch model. Moreover, avenanthramides are a potent antioxidant. This paper will discuss various studies that have found colloidal oatmeal compounds to be beneficial in the treatment of AD and also as adjunctive treatments for AD.

• Authors: Joseph F Fowler Jr
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 13 Issue 10 Pg. 1180-3; quiz 1184-5 (Oct 2014) ISSN: 1545-9616 [Print] United States
• PMID: 25607551 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Colloids
• Dermatologic Agents
• Suspensions
• ortho-Aminobenzoates
• avenanthramide-2C

Topics

• Animals
• Antioxidants (isolation & purification, pharmacology, therapeutic use)
• Avena (chemistry)
• Colloids
• Dermatitis, Atopic (drug therapy, pathology)
• Dermatologic Agents (administration & dosage, pharmacology, therapeutic use)
• Disease Models, Animal
• Humans
• Inflammation (drug therapy, pathology)
• Mice
• Suspensions
• ortho-Aminobenzoates (isolation & purification, pharmacology, therapeutic use)