Abstract | BACKGROUND: METHODS: Sixty-nine patients with inoperable NSCLC were prospectively enrolled (55 M0, 14 M1). OPN plasma levels were measured before (t0), at the end (t1) and four weeks after radiotherapy (t2) by ELISA, compared between M0 and M1 patients and correlated with clinicopathological parameters. OPN levels were monitored over time and correlated with prognosis in M0-stage patients treated by radical 66-Gy radiotherapy ± chemotherapy. RESULTS: Pre-treatment OPN levels were associated with T stage (p = .03), lung function (p = .002), weight loss (p = .01), tumor volume (p = .02) and hemoglobin concentration (p = 04). M1 patients had significantly elevated OPN levels at all time points (p < .001). Patients with increasing OPN levels after radiotherapy had inferior freedom from relapse (p = .008), overall survival (p = .004) and disease-free survival (p = .001) compared to patients with stable or decreasing OPN levels. The risk of relapse in patients with increasing or stable OPN levels after radiotherapy was increased by a factor of 2.9 (p = .01). Patients with increasing post-treatment OPN levels had a 3.1-fold increased risk of death (p = .003). In an exploratory multivariate model, post-treatment OPN level changes but not absolute baseline OPN levels remained an independent prognostic factor for overall survival (p = .002) with a 3.6-fold increased risk of death, as well as N stage (p = .006). CONCLUSIONS: Our results suggest that OPN level changes over time, particularly post-treatment, may yield additional prognostic information in curative-intent radiotherapy of NSCLC.
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Authors | Christian Ostheimer, Matthias Bache, Antje Güttler, Thomas Reese, Dirk Vordermark |
Journal | BMC cancer
(BMC Cancer)
Vol. 14
Pg. 858
(Nov 21 2014)
ISSN: 1471-2407 [Electronic] England |
PMID | 25416631
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Biomarkers
- Carcinoma, Non-Small-Cell Lung
(blood, mortality, pathology, radiotherapy)
- Female
- Humans
- Lung Neoplasms
(blood, mortality, pathology, radiotherapy)
- Male
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
- Osteopontin
(blood)
- Prognosis
- Risk Factors
- Treatment Outcome
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