Higher 17α-hydroxyprogesterone levels aggravated the severity of male adolescent acne in Northeast China.

Abstract

BACKGROUND:

The relationship between serum hormone levels and adolescent acne is not fully clarified.

OBJECTIVE:

To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17α-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China.

METHODS:

A transversal study included 242 acne cases and 188 controls. All data were analyzed using SPSS version 17.0.

RESULTS:

Androstenedione and testosterone levels were significantly higher (p < 0.0001) in the cases than in the control group. In males, the difference in 17-OHP levels was statistically significant (p < 0.0001), as well as between mild and severe acne cases (p = 0.002). The estradiol level was significantly different (p < 0.0001) between cases and controls in females.

CONCLUSION:

Higher androstenedione and testosterone levels are significant risk factors in the occurrence of adolescent acne. A higher 17-OHP level aggravates the severity of male adolescent acne, while a higher estradiol level protects females against the onset of adolescent acne.

• Authors: Bin Wei, Le Qu, Hong Zhu, Ting Xiao, Hua-Chen Wei, Hong-Duo Chen, Chundi He
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 229 Issue 4 Pg. 359-62 ( 2014) ISSN: 1421-9832 [Electronic] Switzerland
• PMID: 25413081 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• progesterone 17 alpha-hydroperoxide
• Testosterone
• Androstenedione
• Progesterone
• Estradiol
• Dehydroepiandrosterone Sulfate

Topics

• Acne Vulgaris (blood)
• Adolescent
• Adult
• Androstenedione (blood)
• Case-Control Studies
• China
• Dehydroepiandrosterone Sulfate (blood)
• Estradiol (blood)
• Female
• Humans
• Male
• Progesterone (analogs & derivatives, blood)
• Risk Factors
• Severity of Illness Index
• Testosterone (blood)
• Young Adult