Skeletal muscle beta 2-adrenoreceptors and the effect of adrenergic drugs on plasma potassium in perinephritis hypertension in rabbits.

Abstract

1. It has been suggested that beta 2-adrenoreceptors in skeletal muscle regulate plasma potassium. The possibility that alterations in the function and/or density of these receptors occurs in perinephritis hypertension in rabbits was studied. 2. Intravenous infusion of adrenaline (0.2 micrograms kg-1 min-1) caused a fall in potassium while intravenous bolus injection of propranolol (0.75 mg kg-1) resulted in an increase in serum potassium which was of similar magnitude in both perinephritis hypertensive and sham-operated normotensive rabbits. 3. Binding studies with the radioligand [125I] cyanopindolol (ICYP) showed that there were no significant differences between the hypertensive and normotensive rabbits in the density (Bmax) or affinity (KD) of the skeletal muscle beta 2-adrenoreceptor. 4. The results suggest that function and density of skeletal muscle beta 2-adrenoreceptors are not altered in rabbits with perinephritis hypertension.

• Authors: M S Elfellah, C A Hamilton, W McIntosh, S M Barr, C Howie, J L Reid
• Journal: Journal of autonomic pharmacology (J Auton Pharmacol) Vol. 9 Issue 2 Pg. 113-8 (Apr 1989) ISSN: 0144-1795 [Print] England
• PMID: 2541134 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Iodine Radioisotopes
• Receptors, Adrenergic, beta
• Sympathomimetics
• Iodocyanopindolol
• Pindolol
• Potassium
• Epinephrine

Topics

• Animals
• Epinephrine (pharmacology)
• Heart Rate (drug effects)
• Hypertension, Renal (blood, metabolism)
• Iodine Radioisotopes
• Iodocyanopindolol
• Male
• Muscles (metabolism)
• Perinephritis (complications)
• Pindolol (analogs & derivatives)
• Potassium (blood)
• Rabbits
• Radioligand Assay
• Receptors, Adrenergic, beta (metabolism)
• Sympathomimetics (pharmacology)