Antinociceptive properties of physalins from Physalis angulata.

Abstract

Pain is the most common reason a patient sees a physician. Nevertheless, the use of typical painkillers is not completely effective in controlling all pain syndromes; therefore further attempts have been made to develop improved analgesic drugs. The present study was undertaken to evaluate the antinociceptive properties of physalins B (1), D (2), F (3), and G (4) isolated from Physalis angulata in inflammatory and centrally mediated pain tests in mice. Systemic pretreatment with 1-4 produced dose-related antinociceptive effects on the writhing and formalin tests, traditional screening tools for the assessment of analgesic drugs. On the other hand, only 3 inhibited inflammatory parameters such as hyperalgesia, edema, and local production of TNF-α following induction with complete Freund's adjuvant. Treatment with 1, 3, and 4 produced an antinociceptive effect on the tail flick test, suggesting a centrally mediated antinociception. Reinforcing this idea, 2-4 enhanced the mice latency reaction time during the hot plate test. Mice treated with physalins did not demonstrate motor performance alterations. These results suggest that 1-4 present antinociceptive properties associated with central, but not anti-inflammatory, events and indicate a new pharmacological property of physalins.

• Authors: Milena da Silva Lima, Afrânio Ferreira Evangelista, Gisele Graça Leite Dos Santos, Ivone Maria Ribeiro, Therezinha Coelho Barbosa Tomassini, Milena Botelho Pereira Soares, Cristiane Flora Villarreal
• Journal: Journal of natural products (J Nat Prod) Vol. 77 Issue 11 Pg. 2397-403 (Nov 26 2014) ISSN: 1520-6025 [Electronic] United States
• PMID: 25396337 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Secosteroids
• Tumor Necrosis Factor-alpha
• physalin D
• physalin G
• physalin B
• physalin F
• Freund's Adjuvant

Topics

• Analgesics (pharmacology)
• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Disease Models, Animal
• Edema (drug therapy)
• Freund's Adjuvant
• Hyperalgesia (drug therapy)
• Male
• Mice
• Molecular Structure
• Pain (drug therapy)
• Pain Measurement
• Physalis (chemistry)
• Secosteroids (chemistry, isolation & purification, pharmacology)
• Tumor Necrosis Factor-alpha (therapeutic use)