Association of interleukin 22 polymorphisms with gastric cancer risk.

Abstract

Interleukin (IL)-22 has been implicated in inflammation and tumorigenesis. To date, no studies have investigated the role of IL-22 polymorphism in the carcinogenesis of gastric cancer (GC). In this study, we aimed to investigate the association of IL-22 polymorphisms with the risk of GC in a Chinese population. One hundred eight GC patients and 110 healthy controls were included in the study. IL-22 rs1179251, rs2227485, and rs2227473 polymorphisms were determined by PCR amplification and DNA sequencing. Haplotypes were constructed, and a possible association of these haplotypes with GC was assessed. The distribution of IL-22 rs1179251 polymorphism with clinical parameters was also analyzed. The IL-22 rs1179251 polymorphism was significantly associated with an increased risk of GC (p < 0.05). Stratified analysis revealed that rs1179251 was associated with advanced stages, lymph node metastases, and distant metastases of GC (p < 0.05). No associations were found between rs2227485 and rs2227473 and the risk of GC (p > 0.05). Three possible haplotypes (C(rs1179251)-C(rs2227485)-G(rs2227485), C(rs1179251)-T(rs2227485)-G(rs2227485), and G(rs1179251)-T(rs2227485)-A(rs2227485)) were identified, but no associations were found between these and the risk of GC (p > 0.05). In summary, our study demonstrates that the rs1179251 polymorphism of IL-22 was associated with an increased risk of GC and may influence the progression of GC. Future larger studies with other ethnic populations are required to confirm these findings.

• Authors: Shan-yu Qin, Xian-wen Yang, Wei Luo, Mei Chen, Zhi-ling Liu, Si-biao Su, Hai-xing Jiang
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 36 Issue 3 Pg. 2033-9 (Mar 2015) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 25387810 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukins

Topics

• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Haplotypes
• Humans
• Interleukins (genetics)
• Male
• Middle Aged
• Polymorphism, Genetic
• Risk
• Stomach Neoplasms (genetics, immunology)
• Interleukin-22