Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice.

Abstract

Grifola frondosa (GF), distributed widely in far east Asia including Korea, is popularly used as traditional medicines and health supplementary foods, especially for enhancing the immune functions of the body. To extend the application of GF polysaccharides (GFP) for atopic dermatitis (AD), we investigated the effects of GFP on the 2,4-dinitrochlorobenzene-induced AD-like skin lesion in NC/Nga mice. GFP treatment significantly reduced the dorsa skin dermatitis score and combination treatment with GFP, and dexamethasone has a synergistic effect in AD-like skin lesion by reduced Serum IgE, mast cells infiltration, and cytokines expression. These results indicate that GFP suppressed the AD-like skin lesions by controlling the Th-1/Th-2-type cytokines in NC/Nga mice. These findings strongly suggest that GFP can be useful for AD patients as a novel therapeutic agent and might be used for corticosteroids replacement or supplement agent.

• Authors: Hyeon Soo Park, Yong Hyeon Hwang, Mun Ki Kim, Gyeong Eun Hong, Ho Jeong Lee, Arulkumar Nagappan, Silvia Yumnam, Eun Hee Kim, Jeong Doo Heo, Sang Joon Lee, Chung Kil Won, Gon Sup Kim
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 79 Issue 1 Pg. 147-54 ( 2015) ISSN: 1347-6947 [Electronic] England
• PMID: 25248662 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Dinitrochlorobenzene
• Plant Extracts
• Polysaccharides
• Solvents
• Water
• Immunoglobulin E
• Dexamethasone

Topics

• Animals
• Anti-Inflammatory Agents (isolation & purification, pharmacology)
• Cell Movement (drug effects)
• Dermatitis, Atopic (chemically induced, drug therapy, immunology, pathology)
• Dexamethasone (pharmacology)
• Dinitrochlorobenzene
• Drug Synergism
• Female
• Grifola (chemistry)
• Immunoglobulin E (blood)
• Mast Cells (drug effects, immunology, pathology)
• Mice
• Plant Extracts (chemistry)
• Polysaccharides (isolation & purification, pharmacology)
• Skin (drug effects, immunology, pathology)
• Solvents
• Th1-Th2 Balance (drug effects)
• Water