Inappropriate prescription of allopurinol and febuxostat and risk of adverse events in the elderly: results from the REPOSI registry.

Abstract

PURPOSE:

To investigate the prevalence of xanthine oxidase (XO) inhibitors prescription at admission and discharge in elderly hospital in-patients, to analyze the appropriateness of their use in relation to evidence-based indications, to evaluate the predictors of inappropriate prescription at discharge and the association with adverse events 3 months after hospital discharge.

METHODS:

This cross-sectional study, based upon a prospective registry, was held in 95 Italian internal medicine and geriatric hospital wards. The sample included 4035 patients aged 65 years or older at admission and 3502 at discharge. The prescription of XO inhibitors was considered appropriate in patients with diagnosis of gout, gout nephropathy, uric acid nephrolithiasis, tophi, and chemotherapy-induced hyperuricemia. In order to evaluate the predictors of inappropriate prescription of XO inhibitors, we compared the characteristics of patients considered inappropriately treated with those appropriately not treated.

RESULTS:

Among the 4035 patients eligible for the analysis, 467 (11.6 %) were treated with allopurinol or febuxostat at hospital admission and 461 (13.2 %) among 3502 patients discharged. At admission, 39 (8.6 %) of patients receiving XO inhibitors and 43 (9.4 %) at discharge were appropriately treated. Among those inappropriately treated, hyperuricemia, polytherapy, chronic renal failure, diabetes, obesity, ischemic cardiomyopathy, heart failure, and cardiac dysrhythmias were associated with greater prescription of XO inhibitors. Prescription of XO inhibitors was associated with a higher risk of adverse clinical events in univariate and multivariate analysis.

CONCLUSIONS:

Prevalence of inappropriate prescription of XO inhibitors remained almost the same at admission and discharge. Inappropriate use of these drugs is principally related to treatment of asymptomatic hyperuricemia and various cardiovascular diseases.

• Authors: L Pasina, A L Brucato, C D Djade, P Di Corato, S Ghidoni, M Tettamanti, C Franchi, F Salerno, S Corrao, A Marengoni, M Marcucci, P M Mannucci, A Nobili, REPOSI Investigators
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 70 Issue 12 Pg. 1495-503 (Dec 2014) ISSN: 1432-1041 [Electronic] Germany
• PMID: 25228251 (Publication Type: Journal Article)

Chemical References

• Gout Suppressants
• Thiazoles
• Febuxostat
• Allopurinol
• Xanthine Oxidase

Topics

• Aged
• Aged, 80 and over
• Allopurinol (adverse effects)
• Cross-Sectional Studies
• Febuxostat
• Female
• Gout Suppressants (adverse effects)
• Hospitals (statistics & numerical data)
• Humans
• Hyperuricemia (drug therapy, epidemiology)
• Inappropriate Prescribing (statistics & numerical data)
• Italy (epidemiology)
• Male
• Patient Admission (statistics & numerical data)
• Patient Discharge (statistics & numerical data)
• Registries
• Risk
• Thiazoles (adverse effects)
• Xanthine Oxidase (antagonists & inhibitors)