Genetic polymorphisms, Biochemical Factors, and Conventional Risk Factors in Young and Elderly North Indian Patients With Acute Myocardial Infarction.

Abstract

This study compared genetic polymorphisms (factor V Leiden [FVL] 1691G/A, factor VII [FVII] 10976G/A, FVII HVR4, platelet membrane glycoproteins GP1BA 1018C/T, GP1BA VNTR, integrin ITGB3 1565T/C, ITGA2 807C/T and methylenetetrahydrofolate reductase [MTHFR] 677C/T), biochemical (fibrinogen and homocysteine), and conventional risk factors in 184 young and 166 elderly north Indian patients with acute myocardial infarction (AMI). Univariate analysis revealed higher prevalence of hypertension and obesity in elderly patients while smoking, alcohol intake, and low socioeconomic status in young patients (P < .001). Although mean fibrinogen predominated (P = .01) in elderly patients, mean homocysteine was higher (P < .001) among young patients. Prevalence of hyperhomocysteinemia was greater in young than in elderly patients (odds ratio: 2.8, 95% confidence interval: 1.8-4.4, P < .001); however, genetic polymorphisms were equally prevalent in young and elderly patients. Multiple logistic regression analysis showed smoking (P < .001), alcohol intake (P = .046), and hyperhomocysteinemia (P = .001) to be associated with AMI in the young patients while hypertension (P = .006) in elderly patients. To conclude, smoking, alcohol intake, and elevated homocysteine are the risk factors for AMI among young while hypertension among elderly patients.

• Authors: Rupinder Kaur, Reena Das, Jasmina Ahluwalia, Rohit Manoj Kumar, K K Talwar
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 22 Issue 2 Pg. 178-83 (Mar 2016) ISSN: 1938-2723 [Electronic] United States
• PMID: 25155498 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2014.

Chemical References

• Antigens, Human Platelet
• Blood Coagulation Factors
• Homocysteine
• MTHFR protein, human
• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Adult
• Aged
• Antigens, Human Platelet (blood, genetics)
• Blood Coagulation Factors (genetics, metabolism)
• Female
• Homocysteine (blood, genetics)
• Humans
• Hyperhomocysteinemia (blood, genetics)
• Hypertension (blood, genetics)
• India
• Male
• Methylenetetrahydrofolate Reductase (NADPH2) (blood, genetics)
• Middle Aged
• Myocardial Infarction (blood, genetics)
• Obesity (blood, genetics)
• Polymorphism, Genetic
• Risk Factors