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Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)

Subscribe to New Research on Methylenetetrahydrofolate Reductase (NADPH2)

A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This enzyme was formerly classified as EC 1.1.1.171.

Also Known As:

Methylenetetrahydrofolate Reductase; 5,10-Methylenetetrahydrofolate Reductase (NADPH); Methylene Tetrahydrofolate Reductase; Methylenetetrahydrofolate Reductase (NADPH); Tetrahydrofolate Reductase, Methylene; Methylene-THF Reductase (NADPH)

Networked: 2069 relevant articles (10 outcomes, 328 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rozen, Rima: 23 articles (04/2015 - 01/2002)
2.	Kim, Nam Keun: 14 articles (10/2014 - 07/2005)
3.	Rozen, R: 12 articles (10/2009 - 01/2000)
4.	Griffiths, Lyn R: 10 articles (09/2015 - 02/2004)
5.	Sazci, Ali: 10 articles (07/2012 - 03/2003)
6.	Oh, Doyeun: 9 articles (01/2015 - 07/2005)
7.	Almawi, Wassim Y: 9 articles (08/2010 - 05/2004)
8.	Blom, H J: 9 articles (02/2006 - 01/2000)
9.	Xu, Xin: 8 articles (10/2015 - 06/2002)
10.	Zintzaras, Elias: 8 articles (08/2015 - 01/2005)

Related Diseases

1.	Rheumatoid Arthritis 06/01/2013 - "C677T and A1298C polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with increased cardiovascular (CV) events in non-rheumatoid arthritis (RA) populations. " 01/01/2010 - "We determined the contribution of the methylene tetrahydrofolate reductase (MTHFR) 677 C>T and 1298 A>C gene polymorphisms to the susceptibility to rheumatoid arthritis (RA). " 01/01/2008 - "The c.1298A>C polymorphism in the methylenetetrahydrofolate reductase gene is associated with rheumatoid arthritis susceptibility in Italian patients." 09/01/2006 - "To determine the allele frequencies of five common coding single-nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene in African-Americans and Caucasians with rheumatoid arthritis and controls to assess whether there are differences in allele frequencies among these ethnic or racial groups and whether these SNPs differentially affect the efficacy or toxicity of MTX. " 01/01/2010 - "The C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene have been reported to be associated with the toxicity and efficacy of methotrexate in rheumatoid arthritis (RA), although the results of previous studies have been inconsistent. "
2.	Stroke (Strokes) 12/01/2015 - "The association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and ischemic stroke (IS) has been extensively studied; however, the results from genetic association studies have been inconsistent even in the Chinese population. " 07/01/2015 - "Studies on association between methylenetetrahydrofolate reductase gene (MTHFR) C677T gene polymorphism and ischemic stroke have shown conflicting results. " 01/01/2015 - "Methylenetetrahydrofolate reductase gene A1298C polymorphism in pediatric stroke--case-control and family-based study." 01/15/2013 - "Although metabolic syndrome (MS) is recognized as a risk factor for ischemic stroke, little is known about genetic variants that confer susceptibility to ischemic stroke among individuals with or without MS. This study was completed to investigate whether the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is associated with MS as a risk factor for ischemic stroke in the Korean population. " 01/01/2013 - "Several independent studies have reported the role of the methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphism in strokes, but the results are inconclusive. "
3.	Hyperhomocysteinemia 07/01/2009 - "Hyperhomocysteinemia is an independent cardiovascular risk factor, according to most observational studies and to studies using the Mendelian randomization approach, utilizing the common polymorphism C677T of methylene tetrahydrofolate reductase. " 12/01/2007 - "The C677T mutation of the methylenetetrahydrofolate reductase gene, which may lead to hyperhomocysteinemia, is also considered a risk factor for VTE in some studies. " 09/01/2004 - "Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been well documented to cause hyperhomocysteinemia, and recent studies suggest an association of C677T mutation of methylenetetrahydrofolate reductase with low bone mineral density (BMD). " 01/01/2003 - "Conflicting data from Western European and USA population studies led us to investigate hyperhomocysteinemia (HHcy), the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms and thrombotic disease in North Western Russia. " 01/01/2003 - "Earlier studies identified a common polymorphism of methylenetetrahydrofolate reductase that was associated with mild hyperhomocysteinemia. "
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/01/2003 - "Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer." 12/20/2006 - "[Genetic polymorphisms in methylenetetrahydrofolate reductase and clinical response to chemotherapy in non-small cell lung cancer]." 01/01/2013 - "Cancer-testis gene expression is associated with the methylenetetrahydrofolate reductase 677 C>T polymorphism in non-small cell lung carcinoma." 03/01/2013 - "The aim of this study was to evaluate the association between the methylenetetrahydrofolate reductase (MTHFR) C677T excision repair cross-complementation group 1 (ERCC1) genetic polymorphisms and the clinical efficacy of gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC). " 11/01/2014 - "Heterozygote advantage of methylenetetrahydrofolate reductase polymorphisms on clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy."
5.	Alzheimer Disease (Alzheimer's Disease) 03/01/2004 - "A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease." 03/01/2009 - "Nutrition is recognized as a significant determinant in several diseases, yet its interaction with polymorphisms, and in general with the genome, has not been properly addressed Mexico has a high prevalence of polymorphisms of the methylenetetrahydrofolate reductase gene, and in both clinical and basic studies this has been associated with an increased susceptibility of developing Alzheimer's disease. " 01/23/2015 - "The association between methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and Alzheimer's Disease (AD) risk has been widely reported with inconsistent results. " 01/01/2015 - "Methylenetetrahydrofolate reductase (MTHFR) gene mutations were studied in consecutive Alzheimer's Disease & Memory Clinic patients up to December 2014. " 09/01/2013 - "Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease."

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	Homocysteine
3.	Folic Acid (Vitamin M)
4.	Vitamins
5.	Vitamin B 12 (Cyanocobalamin)
6.	gemcitabine
7.	Prothrombin (Factor II)
8.	factor V Leiden
9.	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)
10.	Thymidylate Synthase

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Adjuvant Chemotherapy
3.	Renal Dialysis (Hemodialysis)
4.	Aftercare (After-Treatment)
5.	Protein-Restricted Diet (Diet, Protein Restricted)