Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus.

Abstract

Subclinical hypothyroidism (SCH) has been associated with type 2 diabetes mellitus. However, it is unknown whether common complications of type 2 diabetes, such as diabetic nephropathy, are also present with SCH. Here, we investigated the association between SCH and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus. In this multicenter cross-sectional study, we recruited 414 such patients who had no previous history of thyroid disease. Serum thyroid hormone levels and the urinary albumin:creatinine ratio were measured. SCH was defined as an elevated thyroid-stimulating hormone (TSH) level (>4.0 mIU/L), and diabetic nephropathy was defined as urinary albumin/creatinine ratio ≥300 mg/g. The prevalence of SCH was 8.7% (n = 36) among patients with type 2 diabetes mellitus. The SCH group had a higher prevalence of dyslipidemia (p = 0.008) and diabetic nephropathy (p = 0.014) than the euthyroid group. Multivariate analysis identified significant positive associations between diabetic nephropathy and SCH (odds ratio [OR], 3.51; 95% confidence interval [CI], 1.10-10.0; p = 0.034), hypertension (OR, 4.56; 95% CI, 1.69-14.7; p = 0.001), and smoking (OR, 3.02; 95% CI, 1.14-7.91; p = 0.026). SCH may be independently associated with diabetic nephropathy in Japanese patients with type 2 diabetes mellitus.

• Authors: Shinya Furukawa, Shin Yamamoto, Yasuhiko Todo, Kotatsu Maruyama, Teruki Miyake, Teruhisa Ueda, Tetsuji Niiya, Takatoshi Senba, Masamoto Torisu, Teru Kumagi, Syozo Miyauchi, Takenori Sakai, Hisaka Minami, Hiroaki Miyaoka, Bunzo Matsuura, Yoichi Hiasa, Morikazu Onji, Takeshi Tanigawa
• Journal: Endocrine journal (Endocr J) Vol. 61 Issue 10 Pg. 1011-8 ( 2014) ISSN: 1348-4540 [Electronic] Japan
• PMID: 25100149 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Thyrotropin

Topics

• Adult
• Aged
• Aged, 80 and over
• Comorbidity
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (blood, epidemiology)
• Diabetic Nephropathies (blood, epidemiology)
• Dyslipidemias (blood, epidemiology)
• Female
• Humans
• Hypothyroidism (blood, epidemiology)
• Male
• Middle Aged
• Prevalence
• Thyrotropin (blood)
• Young Adult