Abstract |
We investigated plasma metabolite profiles that correlated with age-related serum alanine aminotransferase (ALT) levels. The study included 602 healthy, nondiabetic subjects (aged 30-65 years); 393 individuals had normal ALT levels at baseline. Fifty-three (13.5%) individuals developed elevated ALT levels after 3 years. The remaining 340 subjects with normal ALT were matched to the elevated-ALT group (n = 53) for age, gender, BMI, fasting glucose, and ALT to form the control group (n = 53). At the 3-year follow-up, the elevated-ALT group exhibited greater increases in waist circumference, serum free fatty acid, ALT, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), bilirubin, plasma oxidized LDL, Lp-PLA2 activity, urinary 8-epi-prostaglandin F2α (8-epi-PGF2α), and brachial-ankle pulse-wave velocity (ba-PWV) compared to the control group after baseline adjustment. The elevated-ALT group exhibited greater increases in plasma l-valine (q = 0.036), l-leucine (q = 0.012), l-phenylalanine (q = 0.012), and decanoylcarnitine (q = 0.002). Mean ALT levels positively correlated with changes in these four metabolites, which correlated with changes in AST, GGT, Lp-PLA2 activity, urinary 8-epi-PGF2α, and ba-PWV. Mean ALT changes did not significantly correlate with HOMA- insulin resistance. These results suggest that increased plasma levels of l-valine, l-leucine, l-phenylalanine, and decanoylcarnitine precede insulin resistance during periods of elevated ALT. This metabolic disturbance coincides with enhanced risk factors for cardiovascular disease.
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Authors | Saem Jung, Oh Yoen Kim, Minjoo Kim, Juheui Song, Sang-Hyun Lee, Jong Ho Lee |
Journal | Journal of proteome research
(J Proteome Res)
Vol. 13
Issue 7
Pg. 3467-75
(Jul 03 2014)
ISSN: 1535-3907 [Electronic] United States |
PMID | 24874467
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amino Acids
- Biomarkers
- decanoylcarnitine
- Alanine Transaminase
- Carnitine
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Topics |
- Adult
- Aged
- Aging
(blood)
- Alanine Transaminase
(blood)
- Amino Acids
(blood)
- Biomarkers
(blood)
- Carnitine
(analogs & derivatives, blood)
- Case-Control Studies
- Female
- Humans
- Male
- Middle Aged
- Oxidative Stress
- Prospective Studies
- Vascular Stiffness
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