Non-viral nanocarriers for siRNA delivery in breast cancer.

Abstract

Breast cancer is the most frequently diagnosed malignancy in American women. While significant progress has been made in the development of modern diagnostic tools and surgical treatments, only marginal improvements have been achieved with relapsed metastatic breast cancer. Small interfering RNAs (siRNAs) mediate gene silencing of a target protein by disrupting messenger RNAs in an efficient and sequence-specific manner. One application of this technology is the knockdown of genes responsible for tumorigenesis, including those driving oncogenesis, survival, proliferation and death of cells, angiogenesis, invasion and metastasis, and resistance to treatment. Non-viral nanocarriers have attracted attention based on their potential for targeted delivery of siRNA and efficient gene silencing without toxicity. Here, we review promising, non-viral delivery strategies employing liposomes, nanoparticles and inorganic materials in breast cancer.

• Authors: Jing Zhang, Xiang Li, Leaf Huang
• Journal: Journal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 190 Pg. 440-50 (Sep 28 2014) ISSN: 1873-4995 [Electronic] Netherlands
• PMID: 24874288 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• RNA, Small Interfering

Topics

• Breast Neoplasms (genetics, pathology, therapy)
• Gene Transfer Techniques
• Humans
• Nanoparticles
• RNA, Small Interfering