Abstract | OBJECTIVE: To investigate the expression level of tumor necrosis factor receptor-associated factor 1 ( TRAF1) in gastric mucosa tissue in patients infected with Helicobacter pylori (H. pylori) and to analyze the relationship between TRAF1 expression and H. pylori virulence. METHODS: Gastric tissue samples were collected from patients with gastritis, atrophic gastritis, intestinal metaplasia with atypical hyperplasia, and gastric cancer. The expression level of TRAF1 in each group was analyzed by real-time polymerase chain reaction (PCR) and Western blot analysis. Virulence genotypes of H. pylori were determined by PCR. RESULTS: CONCLUSION: Higher TARF1 expression level is associated with infection by CagA(+)/vacAs1(+)/m1(+) virulent H. pylori strains and may promote the proliferation of gastric mucosal cells and induce gastric cancer.
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Authors | Fen Wang, Guangkui Bu, Qian Feng, Zhiying Liu, Canxia Xu, Shourong Shen, Yi Yuan |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 49
Issue 8
Pg. 925-32
(Aug 2014)
ISSN: 1502-7708 [Electronic] England |
PMID | 24852885
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Bacterial
- Bacterial Proteins
- Biomarkers, Tumor
- RNA, Messenger
- TNF Receptor-Associated Factor 1
- VacA protein, Helicobacter pylori
- Virulence Factors
- cagA protein, Helicobacter pylori
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Topics |
- Antigens, Bacterial
(genetics)
- Bacterial Proteins
(genetics)
- Biomarkers, Tumor
(genetics)
- Gastric Mucosa
(pathology)
- Genotype
- Helicobacter Infections
(complications)
- Helicobacter pylori
(genetics, pathogenicity)
- Humans
- RNA, Messenger
(metabolism)
- Stomach Neoplasms
(genetics, microbiology, pathology)
- TNF Receptor-Associated Factor 1
(genetics, metabolism)
- Virulence Factors
(genetics)
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