Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase.

Abstract

BACKGROUND:

Some hepatitis B extracellular antigen (HBeAg)-positive chronic hepatitis B (CHB) patients in their immune active phase can clear the virus spontaneously and enter into an inactive hepatitis B virus (HBV) carrier state, indicating a benign prognosis. In this study, the association between cytokine-inducible SRC homology 2 domain protein (CISH) gene polymorphisms at -292 (rs414171) and the spontaneous clearance of HBV in HBeAg-positive CHB patients in immune the active phase was investigated.

METHODS:

Seventy HBeAg-positive CHB patients in the immune active phase were followed up for 76 weeks without antiviral therapy. The alanine transaminase, aspartate transaminase, HBV DNA, HBeAg and hepatitis B extracellular antibody levels were tested regularly. At week 76, 27 patients were classified into group A (HBV DNA level below 2 104 IU/ml and the value of HBeAg declined below 10% of the baseline at week 76), and 43 patients were classified into group B (HBV DNA level higher than 2×10(4) IU/ml or the value of HBeAg did not decline substantially at week 76). CISH (rs414171) polymorphisms were also tested using the iPLEX system.

RESULTS:

The HBV DNA levels at week 12 were significantly greater in group B compared with group A (group A: (6.87±1.40) log10IU/ml; group B: (7.61±1.38) log10IU/ml, P = 0.034) and the HBeAg values were greater in group B at week 28 compared with group A (P = 0.001). The differences in HBV DNA and HBeAg values increased between the groups over time. Sixteen patients in group A and 11 in group B were genotype AA. Those with genotype AT or TT included 11 in group A and 31 in group B (AA vs. AT and TT, odds ratio 4.10 (95% confidence interval: 1.462-11.491), P = 0.006).

CONCLUSION:

CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect.

• Authors: Guangjun Song, Huiying Rao, Bo Feng, Lai Wei
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 127 Issue 9 Pg. 1691-5 ( 2014) ISSN: 2542-5641 [Electronic] China
• PMID: 24791876 (Publication Type: Journal Article)

Chemical References

• Hepatitis B e Antigens
• Suppressor of Cytokine Signaling Proteins
• cytokine inducible SH2-containing protein

Topics

• Adolescent
• Adult
• Aged
• Female
• Genotype
• Hepatitis B e Antigens (metabolism)
• Hepatitis B virus (genetics, immunology)
• Hepatitis B, Chronic (immunology)
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• Suppressor of Cytokine Signaling Proteins (genetics)
• Young Adult