Inflammasome activation and vitiligo/nonsegmental vitiligo progression.

Abstract

BACKGROUND:

Polymorphisms of NLR (nucleotide-binding domain and leucine rich repeat containing) family, pyrin domain containing protein 1 (NLRP1) have been found in patients with vitiligo/nonsegmental vitiligo (NSV), and increased NLRP1 expression has been detected in the leading edge of lesional skin biopsies.

OBJECTIVES:

To evaluate the presence and intensity of NLRP1 immunostaining in lesional and perilesional skin of patients with vitiligo/NSV and to search for possible correlations between NLRP1 and interleukin (IL)-1β expression, lymphocytic infiltrates and disease activity.

METHODS:

Of 14 consecutive vitiligo/NSV patients, eight had active disease [Vitiligo European Task Force (VETF) spreading score +1 to +5], one patient had stable disease and five patients had regressive disease (VETF spreading score -1 to -3). We performed immunostaining for NLRP1, B and T lymphocytes, IL-1β and kallikrein 7 on lesional and perilesional vitiligo skin.

RESULTS:

NLRP1 and IL-1β immunostaining in perilesional vitiligo/NSV skin was significantly associated with progressive disease (P = 0·009 and 0·04, respectively) and performed better than the simple detection of lymphocytic infiltrates.

CONCLUSIONS:

Our findings suggest that markers of the NLRP1 inflammasome could be a useful test for assessing disease activity in addition to the detection of inflammatory infiltrates in the progressing margins of vitiligo/NSV lesions.

• Authors: J Marie, D Kovacs, C Pain, T Jouary, C Cota, B Vergier, M Picardo, A Taieb, K Ezzedine, M Cario-André
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 170 Issue 4 Pg. 816-23 (Apr 2014) ISSN: 1365-2133 [Electronic] England
• PMID: 24734946 (Publication Type: Journal Article)
• Copyright: © 2014 British Association of Dermatologists.

Chemical References

• Adaptor Proteins, Signal Transducing
• Apoptosis Regulatory Proteins
• Biomarkers
• Inflammasomes
• Interleukin-1beta
• NLR Proteins
• NLRP1 protein, human
• Kallikreins

Topics

• Adaptor Proteins, Signal Transducing (metabolism)
• Adolescent
• Adult
• Aged
• Apoptosis Regulatory Proteins (metabolism)
• Biomarkers (metabolism)
• Case-Control Studies
• Disease Progression
• Female
• Humans
• Immunohistochemistry
• Inflammasomes (metabolism)
• Interleukin-1beta (metabolism)
• Kallikreins (metabolism)
• Lymphocytes (physiology)
• Male
• Middle Aged
• NLR Proteins
• Vitiligo (diagnosis)