Abstract | PURPOSE: METHODS: Sera from 488,156 individuals were screened for CD in seven Swedish clinical immunology laboratories between 1998 and 2012. In total, 356 out of 1,414 identified IgA deficient adults agreed to participate in this study and were resampled. Forty-seven IgA deficient blood donors served as controls. Analyses of IgG antibodies against tTG and DGP as well as HLA typing were performed and a questionnaire was used to investigate adherence to gluten free diet. Available biopsy results were collected. RESULTS: Out of the 356 IgA deficient resampled adults, 67 (18.8%) were positive for IgG anti-tTG and 79 (22.2%) for IgG anti-DGP, 54 had biopsy confirmed CD. Among the 47 IgA deficient blood donors, 4 (9%) were positive for IgG anti-tTG and 8 (17%) for anti-DGP. Four were diagnosed with biopsy verified CD, however, 2 of the patients were negative for all markers. Sixty-eight of 69 individuals with positive IgG anti-tTG were HLA-DQ2/DQ8 positive whereas 7 (18.9%) of the 37 individuals positive for IgG anti-DGP alone were not. CONCLUSIONS:
IgG anti-tTG seems to be a more reliable marker for CD in IgA deficient adults whereas the diagnostic specificity of anti-DGP appears to be lower. High levels of IgG antibodies against tTG and DGP were frequently found in IgA deficient adults despite adhering to gluten free diet.
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Authors | Ning Wang, Lennart Truedsson, Kerstin Elvin, Bengt A Andersson, Johan Rönnelid, Lucia Mincheva-Nilsson, Annica Lindkvist, Jonas F Ludvigsson, Lennart Hammarström, Charlotte Dahle |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 4
Pg. e93180
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24709954
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Immunoglobulin G
- Gliadin
- Protein Glutamine gamma Glutamyltransferase 2
- Transglutaminases
- GTP-Binding Proteins
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Topics |
- Adult
- Biomarkers
(blood)
- Celiac Disease
(blood, complications, immunology)
- Female
- GTP-Binding Proteins
(immunology)
- Gliadin
(immunology)
- Humans
- IgA Deficiency
(blood, complications, immunology)
- Immunoglobulin G
(blood, immunology)
- Male
- Protein Glutamine gamma Glutamyltransferase 2
- Transglutaminases
(immunology)
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