Association of promoter genetic variants in interleukin-10 and Kawasaki disease with coronary artery aneurysms.

Abstract

BACKGROUND:

Kawasaki disease (KD) is an acute, self-limited vasculitis in infants and young children. Interleukin-10 (IL-10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL-10 serum levels have been reported in the KD patients.

METHODS:

In this study, we investigated whether IL-10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study.

RESULTS:

Higher G allele frequencies of IL-10 at -1082 position were observed in KD patients with CAA compared to the controls (P = 0.016, OR: 2.86, 95% CI, 1.17-6.98). In addition, higher IL-10 GCC haplotype frequencies were also observed in KD patients with CAA (P = 0.016, OR: 2.85, 95% CI, 1.17-6.98).

CONCLUSION:

Our data support the possibility that IL-10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.

• Authors: Ying-Ju Lin, Yu-Ching Lan, Chih-Ho Lai, Ting-Hsu Lin, Shao-Mei Huang, Chiu-Chu Liao, Cheng-Wen Lin, Chien-Hui Hung, Ni Tien, Xiang Liu, Wen-Kuei Chien, Jin-Hua Chen, Fuu-Jen Tsai
• Journal: Journal of clinical laboratory analysis (J Clin Lab Anal) Vol. 28 Issue 6 Pg. 461-4 (Nov 2014) ISSN: 1098-2825 [Electronic] United States
• PMID: 24659220 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 Wiley Periodicals, Inc.

Chemical References

• Interleukin-10

Topics

• Case-Control Studies
• Child
• Child, Preschool
• Coronary Aneurysm (complications, genetics)
• Female
• Gene Frequency
• Haplotypes
• Humans
• Infant
• Interleukin-10 (genetics)
• Male
• Mucocutaneous Lymph Node Syndrome (complications, genetics)
• Polymorphism, Genetic
• Promoter Regions, Genetic (genetics)
• Taiwan