Serum melatonin is an alternative index of Parkinson's disease severity.

Abstract

The protective potential of melatonin (MLT) in Parkinson's disease (PD) is the subject of considerable controversy. The purpose of the present study was to investigate serum MLT levels in unilateral 6-hydroxydopamine (6-OHDA) lesion rats and patients with PD. Blood samples were collected from rats at 10:00 am and from patients with PD and healthy subjects between 8:00 and 10:00 am. Serum MLT levels were measured using the enzyme-linked immunosorbent assay. Our results revealed that the morning serum MLT levels either in 6-OHDA-induced hemi-parkinsonian rats or patients with PD were significantly higher than that of control group. Our results also demonstrate that serum MLT levels are correlated with severity of PD according to H & Y scale.

• Authors: Ling Lin, Yuequn Du, Sutao Yuan, Jie Shen, Xiang Lin, Zhihong Zheng
• Journal: Brain research (Brain Res) Vol. 1547 Pg. 43-8 (Feb 14 2014) ISSN: 1872-6240 [Electronic] Netherlands
• PMID: 24384141 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Dopamine Agonists
• Oxidopamine
• Melatonin
• Apomorphine

Topics

• Aged
• Aged, 80 and over
• Animals
• Apomorphine (pharmacology)
• Biomarkers
• Dopamine Agonists (pharmacology)
• Female
• Humans
• Male
• Melatonin (blood)
• Middle Aged
• Motor Activity (drug effects, physiology)
• Oxidopamine (toxicity)
• Parkinson Disease (blood, diagnosis)
• Rats
• Rats, Sprague-Dawley
• Severity of Illness Index
• Time Factors