Epigallocatechin-3-gallate induces apoptosis, inhibits proliferation and decreases invasion of glioma cell.

Abstract

Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, has been considered a potential therapeutic and chemopreventive agent for cancer. Glioma is a malignant tumor with high mortality but effective therapy has not yet been developed. In this study, we found that EGCG induced apoptosis in U251 glioma cells via the laminin receptor (molecular weight 67 kDa) in a time- and dose-dependent manner, decreased their invasiveness and inhibited their proliferation. The mitogen-activated protein kinase pathway was shown to be involved in glioma cell apoptosis and proliferation. Furthermore, the mRNA levels of matrix metalloproteinase (MMP)-2 and MMP-9 were reduced after EGCG treatment. These results suggest that EGCG has important therapeutic effects with low toxicity and side-effects, and could be used in cancer chemoprevention.

• Authors: Hong Li, Zhe Li, Ya-Ming Xu, Yue Wu, Kang-Kang Yu, Can Zhang, Yong-Hua Ji, Gang Ding, Fu-Xue Chen
• Journal: Neuroscience bulletin (Neurosci Bull) Vol. 30 Issue 1 Pg. 67-73 (Feb 2014) ISSN: 1995-8218 [Electronic] Singapore
• PMID: 24338484 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Catechin
• epigallocatechin gallate
• Matrix Metalloproteinase 9
• Matrix Metalloproteinase 1

Topics

• Anticarcinogenic Agents (therapeutic use)
• Apoptosis (drug effects)
• Catechin (analogs & derivatives, therapeutic use)
• Cell Line, Tumor
• Cell Movement (drug effects)
• Cell Proliferation (drug effects)
• Glioma (drug therapy, metabolism)
• Humans
• MAP Kinase Signaling System (drug effects, physiology)
• Matrix Metalloproteinase 1 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)