Abstract | INTRODUCTION: Due to an extensive use of modern imaging, incidental pancreatic cysts are increasingly diagnosed these days. Fortunately, comprehensive research over the past years has remarkably improved our pathogenetic and clinical understanding of pancreatic cysts that, as we know, are in majority harmless. However, mucinous cysts including intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, as well as solid pseudopapillary neoplasms harbor relevant potential for developing into a lethal invasive cancer and may therefore require immediate surgical resection or at least close surveillance. In order to allow an optimized clinical management, it is crucial to gather reliable information about entity as well as biologic behavior of every cyst detected. Unfortunately, in the absence of reliable biomarkers and by just applying currently available diagnostic means such as clinical and radiologic criteria or cyst fluid cytology, there is still a risk for incorrect preoperative diagnoses. This may be followed by inappropriate treatment possibly resulting in severe morbidity or even mortality. OBJECTIVE:
|
Authors | Hanno Matthaei, Georg Feldmann, Philipp Lingohr, Jörg C Kalff |
Journal | Langenbeck's archives of surgery
(Langenbecks Arch Surg)
Vol. 398
Issue 8
Pg. 1021-7
(Dec 2013)
ISSN: 1435-2451 [Electronic] Germany |
PMID | 24068205
(Publication Type: Journal Article, Review)
|
Chemical References |
|
Topics |
- Biomarkers
(analysis)
- Cyst Fluid
- DNA Mutational Analysis
- Humans
- Incidental Findings
- MicroRNAs
(genetics)
- Molecular Imaging
- Pancreatic Cyst
(diagnosis, genetics, pathology)
- Pathology, Molecular
(methods)
- Precancerous Conditions
(diagnosis, genetics, pathology)
|