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Single and dual crosslinked oxidized methacrylated alginate/PEG hydrogels for bioadhesive applications.

Abstract
A degradable, cytocompatible bioadhesive can facilitate surgical procedures and minimize patient pain and post-surgical complications. In this study a bioadhesive hydrogel system based on oxidized methacrylated alginate/8-arm poly(ethylene glycol) amine (OMA/PEG) has been developed, and the bioadhesive characteristics of the crosslinked OMA/PEG hydrogels evaluated. Here we demonstrate that the swelling behavior, degradation profiles, and storage moduli of crosslinked OMA/PEG hydrogels are tunable by varying the degree of alginate oxidation. The crosslinked OMA/PEG hydrogels exhibit cytocompatibility when cultured with human bone marrow-derived mesenchymal stem cells. In addition, the adhesion strength of these hydrogels, controllable by varying the alginate oxidation level and measured using a porcine skin model, is superior to commercially available fibrin glue. This OMA/PEG hydrogel system with controllable biodegradation and mechanical properties and adhesion strength may be a promising bioadhesive for clinical use in biomedical applications, such as drug delivery, wound closure and healing, biomedical device implantation, and tissue engineering.
AuthorsOju Jeon, Julia E Samorezov, Eben Alsberg
JournalActa biomaterialia (Acta Biomater) Vol. 10 Issue 1 Pg. 47-55 (Jan 2014) ISSN: 1878-7568 [Electronic] England
PMID24035886 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Alginates
  • Cross-Linking Reagents
  • Hexuronic Acids
  • Hydrogels
  • Methacrylates
  • Polyethylene Glycols
  • Glucuronic Acid
Topics
  • Adhesiveness (drug effects)
  • Alginates (chemical synthesis, chemistry, pharmacology)
  • Cell Death (drug effects)
  • Cross-Linking Reagents (pharmacology)
  • Elastic Modulus (drug effects)
  • Glucuronic Acid (chemical synthesis, chemistry, pharmacology)
  • Hexuronic Acids (chemical synthesis, chemistry, pharmacology)
  • Humans
  • Hydrogels
  • Kinetics
  • Mesenchymal Stem Cells (cytology, drug effects)
  • Methacrylates (chemical synthesis, chemistry, pharmacology)
  • Oxidation-Reduction (drug effects)
  • Polyethylene Glycols (chemical synthesis, chemistry, pharmacology)
  • Rheology (drug effects)
  • Time Factors

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