Abstract |
A degradable, cytocompatible bioadhesive can facilitate surgical procedures and minimize patient pain and post-surgical complications. In this study a bioadhesive hydrogel system based on oxidized methacrylated alginate/8-arm poly( ethylene glycol) amine (OMA/PEG) has been developed, and the bioadhesive characteristics of the crosslinked OMA/PEG hydrogels evaluated. Here we demonstrate that the swelling behavior, degradation profiles, and storage moduli of crosslinked OMA/PEG hydrogels are tunable by varying the degree of alginate oxidation. The crosslinked OMA/PEG hydrogels exhibit cytocompatibility when cultured with human bone marrow-derived mesenchymal stem cells. In addition, the adhesion strength of these hydrogels, controllable by varying the alginate oxidation level and measured using a porcine skin model, is superior to commercially available fibrin glue. This OMA/PEG hydrogel system with controllable biodegradation and mechanical properties and adhesion strength may be a promising bioadhesive for clinical use in biomedical applications, such as drug delivery, wound closure and healing, biomedical device implantation, and tissue engineering.
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Authors | Oju Jeon, Julia E Samorezov, Eben Alsberg |
Journal | Acta biomaterialia
(Acta Biomater)
Vol. 10
Issue 1
Pg. 47-55
(Jan 2014)
ISSN: 1878-7568 [Electronic] England |
PMID | 24035886
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Alginates
- Cross-Linking Reagents
- Hexuronic Acids
- Hydrogels
- Methacrylates
- Polyethylene Glycols
- Glucuronic Acid
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Topics |
- Adhesiveness
(drug effects)
- Alginates
(chemical synthesis, chemistry, pharmacology)
- Cell Death
(drug effects)
- Cross-Linking Reagents
(pharmacology)
- Elastic Modulus
(drug effects)
- Glucuronic Acid
(chemical synthesis, chemistry, pharmacology)
- Hexuronic Acids
(chemical synthesis, chemistry, pharmacology)
- Humans
- Hydrogels
- Kinetics
- Mesenchymal Stem Cells
(cytology, drug effects)
- Methacrylates
(chemical synthesis, chemistry, pharmacology)
- Oxidation-Reduction
(drug effects)
- Polyethylene Glycols
(chemical synthesis, chemistry, pharmacology)
- Rheology
(drug effects)
- Time Factors
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