PAP/HIP protein is an obesogenic factor.

Abstract	In this article we report the obesogenic role of the acute phase protein PAP/HIP. We found that the transgenic TgPAP/HIP mice develop spontaneous obesity under standard nutritional conditions, with high levels of glucose, leptin, and LDL and low levels of triglycerides and HDL in blood. Accordingly, PAP/HIP-deficient mice are skinny under standard nutritional conditions. We also found that expression of PAP/HIP is induced in intestinal epithelial cells in response to gavage with olive oil and this induction is AG490 sensitive. We demonstrated that incubation of 3T3-L1 preadipocytes with a low concentration as 1 ng/ml of recombinant PAP/HIP results in accelerated BrdU incorporation in vitro. PAP/HIP-dependent adipocytes growth is sensitive to the MEK inhibitor U0126. Finally, patients with severe obesity present higher blood levels of PAP/HIP than non-obese control individuals. Altogether our data suggest that PAP/HIP could be a mediator of fat tissue development, released by the intestine and induced by the presence of food into the gut.
Authors	Veronique Secq, Cecilia Mallmann, Meritxell Gironella, Belen Lopez, Daniel Closa, Stéphane Garcia, Laurence Christa, Giuseppe Montalto, Nelson Dusetti, Juan L Iovanna
Journal	Journal of cellular physiology (J Cell Physiol) Vol. 229 Issue 2 Pg. 225-31 (Feb 2014) ISSN: 1097-4652 [Electronic] United States
PMID	23881718 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	© 2013 Wiley Periodicals, Inc.
Chemical References	Blood Coagulation Factors Butadienes Nitriles Pancreatitis-Associated Proteins Proteins RNA, Messenger RNA-Binding Proteins RPL29 protein, human Reg3b protein, mouse Ribosomal Proteins U 0126
Topics	3T3-L1 Cells Adipose Tissue (metabolism) Adult Animals Blood Coagulation Factors (genetics, metabolism) Butadienes Female Gene Expression Regulation (physiology) Humans Male Mice Mice, Knockout Mice, Transgenic Middle Aged Nitriles Obesity (genetics, metabolism) Pancreatitis-Associated Proteins Proteins (genetics, metabolism) RNA, Messenger (genetics, metabolism) RNA-Binding Proteins Ribosomal Proteins

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