[The effect of galbanic acid on the course of experimental hepatitis].

Abstract

Administration of galbanic acid isolated from the roots of Ferula kopetdaghensis Eug. Kor. to rats orally in a dose of 50 mg/kg was found to improve the course of toxic hepatitis induced by fourfold subcutaneous injections of a 50% oil solution of CCl4. Galbanic acid produced much more earlier than in control normalization of the activity of the enzymes alanine- and aspartataminotransferase in blood serum, increased glycogen content and improved the parameters of the redox potential of lactic acid-pyruvic acid system in the liver. Galbanic acid exerted the antioxidant effect. In the animals with a developed hepatitis receiving galbanic acid there was a more rapid restoration of intensity of bile secretion, synthesis of bile acids and bilirubin, cholesterol excretion as compared with control.

• Authors: V N Syrov, Z A Khushbaktova, A N Nabiev
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1990 Mar-Apr Vol. 53 Issue 2 Pg. 41-3 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie gal'banovoĭ kisloty na techenie éksperimental'nogo gepatita.
• PMID: 2369953 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Coumarins
• galbanic acid
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Alanine Transaminase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Bile (analysis, drug effects)
• Carbon Tetrachloride Poisoning (complications, drug therapy, metabolism)
• Chemical and Drug Induced Liver Injury (drug therapy, etiology, metabolism)
• Coumarins (therapeutic use)
• Drug Evaluation, Preclinical
• Ferula
• Liver (drug effects, metabolism)
• Male
• Plants, Medicinal
• Plants, Toxic
• Rats
• Time Factors