Abstract | OBJECTIVE: This study was designed to investigate the ameliorative potential of Momordica charantia L. (MC) in tibial and sural nerve transection (TST)-induced neuropathic pain in rats. MATERIALS AND METHODS: TST was performed by sectioning tibial and sural nerve portions (2 mm) of the sciatic nerve, and leaving the common peroneal nerve intact. Acetone drop, pin-prick, hot plate, paint-brush, and walking track tests were performed to assess cold allodynia, mechanical and heat hyperalgesia, and dynamic mechanical allodynia and tibial functional index, respectively. The levels of tumour necrosis factor ( TNF)-alpha and thio- barbituric acid reactive substances ( TBARS) were measured in the sciatic nerve as an index of inflammation and oxidative stress. MC (all doses, orally, once daily) was administered to the rats for 24 consecutive days. RESULTS: TST led to significant development of cold allodynia, mechanical and heat hyperalgesia, dynamic mechanical allodynia, and functional deficit in walking along with rise in the levels of TBARS and TNF-alpha. Administration of MC (200, 400, and 800 mg/kg) significantly attenuated TST-induced behavioural and biochemical changes. Furthermore, pretreatment of BADGE (120 mg/kg, intraperitoneally) abolished the protective effect of MC in TST-induced neuropathic pain. CONCLUSIONS: Collectively, it is speculated that PPAR-gamma agonistic activity, anti-inflammatory, and antioxidative potential is critical for antinociceptive effect of MC in neuropathic pain.
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Authors | Vivek Jain, Ashutosh Pareek, Nishant Paliwal, Yashumati Ratan, Amteshwar Singh Jaggi, Nirmal Singh |
Journal | Nutritional neuroscience
(Nutr Neurosci)
Vol. 17
Issue 2
Pg. 88-96
(Feb 2014)
ISSN: 1476-8305 [Electronic] England |
PMID | 23692809
(Publication Type: Journal Article)
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Chemical References |
- Analgesics
- Anti-Inflammatory Agents
- Antioxidants
- PPAR gamma
- Plant Extracts
- Thiobarbituric Acid Reactive Substances
- Tumor Necrosis Factor-alpha
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Topics |
- Analgesics
(therapeutic use)
- Animals
- Anti-Inflammatory Agents
- Antioxidants
- Female
- Hyperalgesia
(drug therapy, etiology)
- Male
- Momordica charantia
(chemistry)
- Neuralgia
(drug therapy, etiology)
- Oxidative Stress
(drug effects)
- PPAR gamma
(agonists)
- Pain Measurement
- Phytotherapy
- Plant Extracts
(therapeutic use)
- Rats
- Rats, Wistar
- Sciatic Nerve
(chemistry)
- Sural Nerve
(surgery)
- Thiobarbituric Acid Reactive Substances
(analysis)
- Tibial Nerve
(surgery)
- Tumor Necrosis Factor-alpha
(analysis)
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