Abstract |
Fractional exhaled nitric oxide (FENO) may be a pulmonary biomarker in chronic obstructive pulmonary disease ( COPD). In this prospective study, the relationship between FENO and airway inflammation was assessed in COPD exacerbations. FENO and lung function were measured, and sputum was collected from 49 ex-smoking COPD patients, first at the time of hospital admission and again at discharge following treatment. There was a significant positive correlation between the percentage of sputum eosinophils and FENO concentrations, both at exacerbation (r = 0.593, p < 0.001) and discharge (r = 0.337, p = 0.044). The increase in forced expiratory volume in one second (FEV(1)) after treatment was greater in patients with sputum eosinophilia (ΔFEV(1) 0.35 ± 0.12 vs. 0.13 ± 0.04 L, p = 0.046), and FENO was a strong predictor of sputum eosinophilia (area under the receiver operating characteristic curve, 0.89). The optimum cut point was 19 parts per billion (sensitivity: 90 %; specificity: 74 %). Our data suggest that FENO is a good surrogate marker of eosinophilic inflammation in COPD patients with exacerbations.
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Authors | Szabolcs Soter, Imre Barta, Balazs Antus |
Journal | Inflammation
(Inflammation)
Vol. 36
Issue 5
Pg. 1178-85
(Oct 2013)
ISSN: 1573-2576 [Electronic] United States |
PMID | 23681903
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Biomarkers
- Eosinophilia
(physiopathology)
- Exhalation
- Female
- Forced Expiratory Volume
- Humans
- Inflammation
(immunology)
- Leukocyte Count
- Lung
(physiopathology)
- Male
- Nitric Oxide
(analysis)
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
(physiopathology)
- Respiratory Function Tests
- Smoking
(immunology)
- Smoking Cessation
- Sputum
(cytology)
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