Abstract | OBJECTIVES: The aim of the present study was to determine the efficacy of oral magnesium (Mg) supplementation on endothelial function through evaluation of carotid intima-media thickness (cIMT), brachial artery flow-mediated dilatation (FMD), and C-reactive protein (CRP) among hemodialysis (HD) patients. METHODS: This randomized, controlled, double-blind clinical trial consisted of 54 patients on HD. One group was treated orally with 440 mg of Mg oxide 3 times per week for 6 months (n = 29). The control group (n = 25) was given placebo using the same administration protocol. cIMT, FMD, serum calcium levels, phosphorus, lipid, CRP, and bicarbonate were measured at baseline and at 6 months in both groups. RESULTS: At 6 months, cIMT was significantly decreased in the Mg group (0.84 ± 0.13 mm at baseline and 0.76 ± 0.13 mm at 6 months, p = 0.001). However, in the placebo group, cIMT was significantly increased (0.73 ± 0.13 and 0.79 ± 0.12 mm, respectively, p = 0.003). When hypertension, diabetes mellitus, smoking, hyperlipidemia, and systemic lupus erythematosus were controlled for in the analysis, the effect of Mg remained significant in both groups (p = 0.000). CONCLUSION: Our results indicate that Mg might not improve endothelial function (CRP level and FMD) and that a decreased cIMT as a marker of atherosclerosis may be due to the inhibition of calcification through the regulation parathormone, calcium, and phosphorus.
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Authors | Mojgan Mortazavi, Firouzeh Moeinzadeh, Mohammad Saadatnia, Shahrzad Shahidi, Jeanie C McGee, Alireza Minagar |
Journal | European neurology
(Eur Neurol)
Vol. 69
Issue 5
Pg. 309-16
( 2013)
ISSN: 1421-9913 [Electronic] Switzerland |
PMID | 23548855
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Adult
- Aged
- Analysis of Variance
- Brachial Artery
(diagnostic imaging, physiopathology)
- Carotid Arteries
(diagnostic imaging, physiopathology)
- Carotid Intima-Media Thickness
- Dilatation
(methods)
- Double-Blind Method
- Female
- Follow-Up Studies
- Humans
- Kidney Diseases
(therapy)
- Magnesium
(administration & dosage, blood)
- Male
- Middle Aged
- Regression Analysis
- Renal Dialysis
(adverse effects)
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