Abstract | BACKGROUND: METHODS: RESULTS:
Trauma and consecutive fluid resuscitation resulted in impaired coagulation parameters (cell count, pH, PT, fibrinogen, ROTEM, and platelet function). During hypothermia, coagulation parameters measured at 37°C, such as PT, fibrinogen, thrombelastometry measurements, and platelet function, showed no significant differences between normothermic and hypothermic animals in both trauma groups. Additional analyses of thrombelastometry at 34°C during hypothermia showed significant differences for clotting time and clot formation time but not for maximum clot firmness. We were not able to detect macroscopic or petechial bleeding in both trauma groups. CONCLUSION: Based on the results of the present study we suggest that mild hypothermia can be safely performed after stabilization following major trauma. Mild hypothermia has effects on the coagulation system but does not aggravate trauma-induced coagulopathy in our model. Before hypothermic treatment can be performed in the clinical setting, additional experiments with prolonged and deeper hypothermia to exclude detrimental effects are required.
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Authors | Juliane Mohr, Steffen Ruchholtz, Frank Hildebrand, Sascha Flohé, Michael Frink, Ingo Witte, Matthias Weuster, Matthias Fröhlich, Martijn van Griensven, Claudia Keibl, Philipp Mommsen |
Journal | The journal of trauma and acute care surgery
(J Trauma Acute Care Surg)
Vol. 74
Issue 4
Pg. 1014-20
(Apr 2013)
ISSN: 2163-0763 [Electronic] United States |
PMID | 23511139
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Animals
- Blood Coagulation
(physiology)
- Blood Coagulation Disorders
(blood, etiology, therapy)
- Blood Coagulation Tests
- Disease Models, Animal
- Hypothermia, Induced
- Male
- Multiple Trauma
(blood, complications, therapy)
- Swine
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