Induced Hypothermia

Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.

Also Known As:

Networked: 963 relevant articles (68 outcomes, 122 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Friberg, Hans: 20 articles (08/2015 - 07/2004)
2.	Cronberg, Tobias: 11 articles (08/2015 - 07/2004)
3.	Nielsen, Niklas: 10 articles (08/2015 - 07/2004)
4.	Rundgren, Malin: 8 articles (04/2014 - 06/2006)
5.	Callaway, Clifton W: 7 articles (12/2015 - 07/2002)
6.	Horn, Janneke: 7 articles (08/2015 - 01/2010)
7.	Holzer, Michael: 7 articles (05/2014 - 07/2003)
8.	Kochanek, Patrick M: 7 articles (09/2013 - 03/2005)
9.	Erlinge, David: 6 articles (04/2015 - 10/2010)
10.	Hildebrand, Frank: 6 articles (12/2014 - 03/2004)

Related Diseases

1.	Heart Arrest (Cardiac Arrest) 12/01/2014 - "In this registry study of an in-hospital cardiac arrest population treated with mild induced hypothermia, we found a 41% good outcome at hospital discharge and 34% at follow-up. " 09/01/2012 - "Pharmacologically induced hypothermia with WIN55, 212-2 improved post-resuscitation myocardial and cerebral function, associated with a significantly increased duration of survival in a rat post-cardiac arrest model. " 10/01/2010 - "In the context of a community-wide focus on resuscitation, the sequential implementation of 2005 American Heart Association guidelines for compressions, ventilations, and induced hypothermia significantly improved survival after cardiac arrest. " 01/01/2014 - "In a rat model of cardiac arrest, better postresuscitation myocardial function, neurological deficit scores, and longer duration of survival were observed by the pharmacologically induced hypothermia with WIN55, 212-2. The improved outcomes of cardiopulmonary resuscitation following administration of WIN55, 212-2 appeared to be the results from its temperature reduction effects." 07/01/2015 - "The present study evaluated the efficacy of pharmacologically induced hypothermia on survival and neurological outcome in rats resuscitated from cardiac arrest. "
2.	Hypothermia 01/01/2011 - "On review, our findings revealed that the protective effects of induced mild hypothermia (33°C) were limited, and the therapeutic time window of even moderate hypothermia (30°C) was very short in our specific models, although this limitation might be due to the relatively brief periods of hypothermia used. " 01/03/2012 - "In a rat model of cardiopulmonary resuscitation, a shorter duration of mild hypothermia induced rapidly and early after restoration of spontaneous circulation improved postresuscitation microcirculation, myocardial and cerebral functions, and survival as well as, or better than, prolonged duration of hypothermia after resuscitation." 06/01/2010 - "Experimental and clinical data indicate that induced hypothermia reduces cerebral hypoxic ischaemic injury and randomized clinical trials in newborns with hypoxic ischaemic encephalopathy confirm improved neurological outcomes and survival at 18 months of age with therapeutic hypothermia. " 08/01/2012 - "Favourable neuro-protective effects are associated with induced hypothermia and international recommendations exist for therapeutic hypothermia. " 05/15/2003 - "Although efficacy of hypothermia in improving functional outcome of mild to moderate traumatic SCI has been demonstrated, hypothermia may not be protective against severe traumatic SCI. At present, induced hypothermia has yet to be recognized or approved as a potential treatment having therapeutic value for traumatic SCI in humans. "
3.	Stroke (Strokes) 06/01/2004 - "Preliminary data suggest that induced hypothermia is feasible and relatively safe in acute stroke patients; this may lead to a better outcome in terms of reduced mortality and less disabling sequelae in survivors. " 01/01/2014 - "Although dosages cannot be directly translated to patients, our study exemplifies in an animal model that drug-induced hypothermia in a clinical setting might reduce cerebral ischemic damage before neuro- and cardiac surgical procedures and after stroke." 03/15/2008 - "Articles including severe, massive, malignant or hemispheric ischemic stroke, induced hypothermia, and animal studies with focal cerebral or brain ischemic models were considered. " 12/01/2007 - "Induced hypothermia is proposed as a treatment for acute ischaemic stroke, but there have been too few clinical trials involving too few patients to draw any conclusions about the therapeutic benefit of cooling. " 09/01/2002 - "Critical issues that will need to be considered in a well designed randomised controlled trial of induced hypothermia in acute stroke patients are discussed."
4.	Brain Injuries (Brain Injury) 04/01/2004 - "Although induced hypothermia appears to be a highly promising treatment in various forms of neurological injury including traumatic brain injury, the difficulties in realising its therapeutic potential are underscored by the negative results from a large multi-center trial. " 01/01/2007 - "Neither any neuroprotective drug has been shown to be beneficial in improving the outcome of severe traumatic brain injury (TBI) nor has any prophylactically-induced moderate hypothermia shown any beneficial effect on outcome in severe TBI, despite the optimism generated by preclinical studies. " 09/01/2007 - "Experimental studies have demonstrated the neuroprotective effects of induced hypothermia in prevention of secondary insults following acute brain injury. " 09/01/2006 - "Although these meta-analyses included trials containing adult patients, a phase II trial of induced hypothermia in pediatric traumatic brain injury has established its feasibility and safety in infants and children. " 09/01/2006 - "Both meta-analyses included trials of adult patients with severe traumatic brain injury randomized to induced hypothermia or normothermia and evaluated risk of death and poor neurologic outcomes. "
5.	Wounds and Injuries (Trauma) 01/01/1997 - "Importantly, these data demonstrate the limited neuroprotective efficacy of DM when attempting to combat more severe focal ischemic injuries and imply that drug-induced hypothermia is not ultimately responsible for its protective action." 01/01/2012 - "Although information regarding severe trauma is limited, there is evidence that induced hypothermia may have beneficial effects on the posttraumatic immune response as well as apoptosis in animal studies and certain clinical situations. " 03/01/2004 - "Further studies are needed to investigate the impact of induced hypothermia on outcome in trauma patients." 07/01/2015 - "Our results suggest that pre-hospital induced hypothermia can be performed carefully following major trauma." 06/01/2015 - "Induced hypothermia for trauma-related ARDS."

Related Drugs and Biologics

1.	Oxygen
2.	Ethanol (Ethyl Alcohol)
3.	Adenosine
4.	Neurotensin Receptors (Neurotensin Receptor)
5.	3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP)
6.	Yohimbine (Yocon)
7.	Cytokines
8.	Ketamine
9.	alpha-MSH
10.	Adenosine Monophosphate (AMP)

Related Therapies and Procedures

1.	Resuscitation
2.	Anesthesia
3.	Cardiopulmonary Resuscitation (CPR)
4.	Induced Hypothermia
5.	Analgesia