Early decrease of serum biomarkers of type II collagen degradation (Coll2-1) and joint inflammation (Coll2-1 NO₂ ) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: a research study part of the Biovisco study.
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| Abstract |
To measure the evolution of the serum levels of specific Osteoarthritis (OA) biomarker, Coll2-1 and Coll2-1 NO₂ in knee osteoarthritic patients after viscosupplementation (VS). Fifty-one patients with unilateral symptomatic knee were recruited for this prospective open label study. They received three intra-articular injections of 2 ml of hyaluronic acid (Hylan GF-20) and were followed for 3 months. Walking pain was evaluated and serum samples were taken at each visit. Coll2-1 and Coll2-1 NO₂ were measured in the serum using specific immunoassays. Variations over time of each parameter and predictive factor of response were studied. Forty-five patients were analyzed. The serum concentrations of Coll2-1 and Coll2-1 NO₂ were significantly higher in KL III/IV patients compared to KL I/II patients at baseline and decreased systematically over time after VS. Its effect was ever more pronounced in patients with KL III/IV. The serum concentration of Coll2-1 was significantly lower at baseline in responders than in non-responders. This study suggests a rapid slowdown of type II collagen degradation and joint inflammation after VS with Hylan G-20 and gives additional information for the validation of accurate biomarkers for OA. The serum level of Coll2-1 appeared to be a predictive factor for response to treatment.
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| Authors | Y Henrotin, X Chevalier, M Deberg, J C Balblanc, P Richette, D Mulleman, B Maillet, F Rannou, C Piroth, P Mathieu, T Conrozier, Osteoarthritis Group of French Society of Rheumatology |
| Journal | Journal of orthopaedic research : official publication of the Orthopaedic Research Society (J Orthop Res) Vol. 31 Issue 6 Pg. 901-7 (Jun 2013) ISSN: 1554-527X [Electronic] United States |
| PMID | 23423846 (Publication Type: Clinical Trial, Journal Article, Multicenter Study) |
| Copyright | Copyright © 2013 Orthopaedic Research Society. |
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