Dietary component p-coumaric acid suppresses monosodium urate crystal-induced inflammation in rats.

Abstract

OBJECTIVE:

This study was conducted to evaluate the effect of p-Coumaric acid, a common dietary phenol, on monosodium urate crystal-induced inflammation in rats-an experimental model for acute gouty arthritis.

METHODS:

Paw edema, levels/activities of lysosomal enzymes, lipid peroxidation, enzymic antioxidants and a histopathological examination of ankle joints were evaluated in control and monosodium urate crystal-induced inflamed rats. Further, an acetic acid-induced writhing test and tail immersion test were employed to screen for analgesic effects, yeast-induced pyrexia was used to test for antipyretic effects, and gastric ulceration was used to evaluate ulcerogenic effects.

RESULTS:

A significant increase in paw edema, lysosomal enzyme activity and lipid peroxidation levels was observed in monosodium urate crystal-induced rats, whereas activities of enzymic antioxidants were found to be decreased when compared to control rats. Nevertheless, treatment with p-Coumaric acid (100 mg/kg b.wt) significantly reverted the altered physical and biochemical parameters back to near normal levels, as evidenced by the histopathology of the ankle joints. In addition, p-Coumaric acid also exhibited potent analgesic and antipyretic effects devoid of any adverse impact on gastric mucosa.

CONCLUSION:

The results of this study reveal the potential anti-inflammatory effect of p-Coumaric acid against monosodium urate crystal-induced inflammation in rats.

• Authors: Samuel Joshua Pragasam, Mahaboobkhan Rasool
• Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (Inflamm Res) Vol. 62 Issue 5 Pg. 489-98 (May 2013) ISSN: 1420-908X [Electronic] Switzerland
• PMID: 23420453 (Publication Type: Journal Article)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Antipyretics
• Coumaric Acids
• Propionates
• Uric Acid
• Catalase
• Superoxide Dismutase
• Acid Phosphatase
• Hexosaminidases
• beta-Glucosidase
• Glucuronidase
• p-coumaric acid
• Acetic Acid

Topics

• Acetic Acid
• Acid Phosphatase (metabolism)
• Analgesics (pharmacology, therapeutic use)
• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Antipyretics (pharmacology, therapeutic use)
• Catalase (metabolism)
• Coumaric Acids (pharmacology, therapeutic use)
• Diet
• Female
• Fever (chemically induced, drug therapy)
• Glucuronidase (metabolism)
• Hexosaminidases (metabolism)
• Inflammation (chemically induced, drug therapy, metabolism, pathology)
• Lipid Peroxidation
• Male
• Pain (chemically induced, drug therapy, physiopathology)
• Propionates
• Rats
• Rats, Wistar
• Saccharomyces cerevisiae
• Superoxide Dismutase (metabolism)
• Uric Acid
• beta-Glucosidase (metabolism)