Abstract | BACKGROUND:
Costello syndrome is a rare genetic condition characterized by coarse facies, short stature, loose folds of skin especially on hands and feet, severe feeding difficulties and failure to thrive. Other features include cardiac anomalies, developmental disability and increased risk of neoplasms. Given the link between oxidative stress (OS) and carcinogenesis, we tested the hypothesis that OS occurs in this syndrome, supposing its role both in cancer development and in other clinical features. PATIENTS AND METHODS: RESULTS: A progressive decrease in OS biomarkers occurred, together with an improvement in the clinical features of the patients. CONCLUSION:
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Authors | Cecilia Anichini, Federica Lotti, Alice Pietrini, Caterina Lo Rizzo, Mariangela Longini, Fabrizio Proietti, Cosetta Felici, Giuseppe Buonocore |
Journal | Anticancer research
(Anticancer Res)
Vol. 33
Issue 2
Pg. 691-5
(Feb 2013)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 23393369
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Ribose
- Ascorbic Acid
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Topics |
- Antioxidants
(therapeutic use)
- Ascorbic Acid
(therapeutic use)
- Costello Syndrome
(drug therapy, metabolism, physiopathology)
- Female
- Humans
- Infant, Newborn
- Male
- Oxidation-Reduction
- Oxidative Stress
- Ribose
(therapeutic use)
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