Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats.

Abstract

BACKGROUND:

Resveratrol (trans-3,4',5-trihydroxystilbene) is a naturally occurring phytoalexin produced by plants in response to various stresses. Several studies have shown that resveratrol is present in significant amounts in a variety of human diets, including wines, grapes, berries, and peanuts, and it possesses several beneficial health properties, such as atheroprotective, anti-obesity, anti-cancer, anti-inflammatory and antioxidant activities. In this study, we evaluated the effect of resveratrol on the pathogenesis of obesity and the metabolic profile of nutrients in non-high fat-fed obese OLETF rats.

RESULTS:

Although lipid parameters in the serum and liver were not changed, the accumulation of abdominal white adipose tissues was markedly prevented in resveratrol diet-fed OLETF rats after 4 weeks of feeding. The results of the respiratory gas analysis indicated that dietary resveratrol induced the partial enhancement of fat metabolism and sparing actions for carbohydrate and protein at 1 week and 3 weeks of feeding in OLETF rats. Additionally, the adipose mRNA level of carnitine palmitoyltransferase in the resveratrol diet-fed OLETF rats was higher than the control rats after 4 weeks of feeding.

CONCLUSION:

Our study demonstrated that dietary resveratrol can prevent obesity through a change in the metabolic profile of nutrients in obese OLETF rats.

• Authors: Koji Nagao, Tomoyuki Jinnouchi, Shunichi Kai, Teruyoshi Yanagita
• Journal: Lipids in health and disease (Lipids Health Dis) Vol. 12 Pg. 8 (Feb 04 2013) ISSN: 1476-511X [Electronic] England
• PMID: 23374859 (Publication Type: Journal Article)

Chemical References

• RNA, Messenger
• Stilbenes
• Triglycerides
• Glycogen
• Cholesterol
• Carnitine O-Palmitoyltransferase
• Resveratrol

Topics

• Adipose Tissue, White (drug effects, metabolism)
• Animals
• Body Weight (drug effects)
• Carnitine O-Palmitoyltransferase (genetics, metabolism)
• Cholesterol (metabolism)
• Food, Formulated
• Gene Expression (drug effects)
• Glycogen (metabolism)
• Lipid Metabolism (drug effects)
• Liver (drug effects, metabolism)
• Male
• Metabolome
• Obesity (metabolism, prevention & control)
• RNA, Messenger (genetics)
• Rats
• Rats, Inbred OLETF
• Resveratrol
• Stilbenes (administration & dosage)
• Triglycerides (metabolism)
• Up-Regulation