Abstract | BACKGROUND: METHODS: RESULTS: Twenty-two patients had Crohn's disease and four had ulcerative colitis. Fistulae and abscesses occurred in ten cases, all of whom had Crohn's disease. Amyloidotic proteinuric renal dysfunction occurred in all of the cases. It resolved in five patients with well-controlled inflammation, but was progressive in all of the other patients. Fifteen patients reached end-stage renal disease after a median time of 6.3 years from development of renal dysfunction (by Kaplan-Meier estimate), six of whom subsequently proceeded to renal transplantation. There were five functioning grafts at census 0.8, 3.2, 4.2, 20.1 and 24.6 years after transplantation. One graft failed 14.5 years after renal transplantation because of amyloid recurrence in a patient with sustained chronic inflammatory activity. CONCLUSIONS:
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Authors | Prayman T Sattianayagam, Julian D Gillmore, Jennifer H Pinney, Simon D J Gibbs, Ashutosh D Wechalekar, Janet A Gilbertson, Dorota Rowczenio, Philip N Hawkins, Helen J Lachmann |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 58
Issue 6
Pg. 1689-97
(Jun 2013)
ISSN: 1573-2568 [Electronic] United States |
PMID | 23371008
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Biomarkers
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Topics |
- Adolescent
- Adult
- Aged
- Amyloidosis
(diagnosis, etiology, metabolism, therapy)
- Anti-Inflammatory Agents
(therapeutic use)
- Biomarkers
(metabolism)
- Child
- Colitis, Ulcerative
(complications, therapy)
- Combined Modality Therapy
- Crohn Disease
(complications, therapy)
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Kidney Diseases
(diagnosis, etiology, metabolism, therapy)
- Kidney Failure, Chronic
(diagnosis, etiology, surgery)
- Kidney Transplantation
- Male
- Middle Aged
- Phenotype
- Prospective Studies
- Treatment Outcome
- Young Adult
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