Abstract | OBJECTIVE: METHODS: Patients were randomized to receive 40 mg parecoxib intravenously either before or after skin incision (preincisional and postincisional groups, respectively). Morphine was administered for postoperative analgesia. Visual analogue pain scale (VAS) scores and morphine consumption were recorded at 1, 6, 18 and 24 h postoperation. Plasma levels of interleukin (IL)-6, IL-8 and tumour necrosis factor-α were measured 30 min before skin incision and 6 h postoperation. RESULTS: Compared with the postincisional group, VAS pain scores at 1 and 6 h postoperation were significantly lower in the preincisional group. Morphine consumption was significantly lower in the preincisional group at 6, 18 and 24 h postoperation. In both groups, IL-6 and IL-8 levels increased significantly at 6 h postoperation compared with preoperation, and the preincisional group had significantly lower levels of IL-6 and IL-8 at 6 h postoperation compared with the postincisional group. CONCLUSIONS:
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Authors | Y Bao, J Fang, L Peng, Y Yi, K Liu, W Li, H Luo |
Journal | The Journal of international medical research
(J Int Med Res)
Vol. 40
Issue 5
Pg. 1804-11
( 2012)
ISSN: 1473-2300 [Electronic] England |
PMID | 23206461
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Opioid
- Cyclooxygenase 2 Inhibitors
- Cytokines
- Isoxazoles
- Morphine
- parecoxib
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Topics |
- Aged
- Analgesics, Opioid
(administration & dosage)
- Arthroplasty, Replacement, Hip
- Cyclooxygenase 2 Inhibitors
(administration & dosage)
- Cytokines
(blood)
- Female
- Femur Head Necrosis
(blood, surgery)
- Hip Fractures
(blood, surgery)
- Humans
- Isoxazoles
(administration & dosage)
- Male
- Middle Aged
- Morphine
(administration & dosage)
- Pain Management
- Pain Measurement
- Pain, Postoperative
(drug therapy)
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