Abstract |
Pleurotus eryngii is a nutritional and medicinal food rich in polysaccharides that enhance the host immune system as a response to various diseases. The present study investigated the effects of P. eryngii extracts (PEE) on the progress of atopic dermatitis (AD)-like skin lesions in NC/Nga mice induced by 2,4-dinitrochlorobenzene ( DNCB). We evaluated skin dermatitis severity, ear thickness, histopathological examination, and cytokines level in DNCB-applied mice treated with PEE. Continuous treatment of PEE inhibited the development of the AD-like skin lesions. PEE suppressed DNCB-induced dermatitis severity, serum level of IgE and thymus and activation-regulated chemokine (TARC), and mRNA expression of TNF-α, INF-γ, IL-4, IL-5, and IL-13 in mice. In addition, PEE reduced thickness of the dermis and dermal infiltration of inflammatory cells and mast cells in histopathological examination. These results indicate that PEE inhibits allergic contact dermatitis through the modulating of T helper (Th)1 and Th2 responses and diminishing the inflammatory cells and mast cells infiltration in the skin lesions in NC/Nga mice.
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Authors | Jae Ho Choi, Hyung Gyun Kim, Sun Woo Jin, Eun Hee Han, Tilak Khanal, Minh Truong Do, Yong Pil Hwang, Jun Min Choi, Sung-Sik Chun, Young Chul Chung, Tae Cheon Jeong, Hye Gwang Jeong |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 53
Pg. 38-45
(Mar 2013)
ISSN: 1873-6351 [Electronic] England |
PMID | 23200891
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Ltd. All rights reserved. |
Chemical References |
- Chemokine CCL17
- Dinitrochlorobenzene
- Interleukin-13
- Interleukin-5
- RNA, Messenger
- Tumor Necrosis Factor-alpha
- Interleukin-4
- Immunoglobulin E
- Interferon-gamma
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Topics |
- Animals
- Chemokine CCL17
(blood)
- Dermatitis, Atopic
(chemically induced, drug therapy, pathology)
- Dinitrochlorobenzene
(adverse effects)
- Immunoglobulin E
(blood)
- Interferon-gamma
(genetics, metabolism)
- Interleukin-13
(genetics, metabolism)
- Interleukin-4
(genetics, metabolism)
- Interleukin-5
(genetics, metabolism)
- Male
- Mast Cells
(drug effects, metabolism)
- Mice
- Pleurotus
- RNA, Messenger
(genetics, metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Th1-Th2 Balance
(drug effects)
- Tumor Necrosis Factor-alpha
(genetics, metabolism)
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