Abstract |
Recent research findings suggest that vascular endothelial growth factor ( VEGF) participates in the development of depressive disorder. VEGF is involved in neurogenesis and neuroprotection processes, mediated by vascular endothelial growth factor receptor 2 (VEGFR2). VEGFR2 also plays a role in angiogenesis, a process related to neurogenesis and other biological processes. We examined VEGFR2 (KDR) gene polymorphism, mRNA expression levels, as well as VEGFR2 protein levels in 268 patients diagnosed with a recurrent depressive disorder (rDD) using the ICD-10 criteria, and in 200 healthy controls. Genotyping and gene expression level analysis was performed using polymerase chain reaction (PCR)-based methods. An Enzyme-Linked Immunosorbent Assay (ELISA) was used for measurement of KDR protein levels. Our study found that distribution of KDR polymorphism +1416T/A differs significantly in patients with rDD when compared to healthy subjects, while A allele and AA genotype are risk factors for rDD. KDR mRNA and protein expression are higher in patients with rDD. We also observed a significant association between the -271A/G variant and gene and protein levels. Our study is the first to demonstrate that the KDR gene may serve as a novel genetic marker that could participate in the etiology of rDD. This new pathway may play a role in the inflammatory pathophysiology of depression.
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Authors | Piotr Gałecki, Agata Orzechowska, Dominika Berent, Monika Talarowska, Kinga Bobińska, Elżbieta Gałecka, Andrzej Lewiński, Michael Maes, Janusz Szemraj |
Journal | Journal of affective disorders
(J Affect Disord)
Vol. 147
Issue 1-3
Pg. 144-9
(May 2013)
ISSN: 1573-2517 [Electronic] Netherlands |
PMID | 23164459
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Chemical References |
- RNA, Messenger
- Vascular Endothelial Growth Factor Receptor-2
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Topics |
- Adult
- Depressive Disorder
(genetics, metabolism, physiopathology)
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
- RNA, Messenger
(biosynthesis)
- Recurrence
- Vascular Endothelial Growth Factor Receptor-2
(biosynthesis, genetics)
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