Evaluation of interleukin-23 plasma levels in patients with polycythemia vera and essential thrombocythemia.

Abstract

Essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis share the same acquired genetic lesion, JAK2V617F. It is believed that cytokines participate in the activation of JAK2V617F. In this study, we analyzed the plasma levels of interleukin (IL)-23, IL-10 and IL-22 in patients with PV and ET. In the same subjects we also performed analysis of the JAK2(V617F) mutation, and evaluated a possible relationship between interleukin levels and thrombotic complications or with the symptom pruritus. Plasma levels of IL-23 were significantly increased in all patients with MPN in comparison to controls. Moreover, there was a significant difference between the levels of IL-23 in patients affected by PV and those measured in controls (8.57±3.69pg/mL vs. 6.55±4.125pg/mL; p<0.03). No difference was found between IL-23 levels in ET patients and controls. No statistically significant differences were found between the levels of IL-23, Il-22 or IL-10 in PV or ET subjects with or without thrombosis, in patients with or without pruritus, or according the JAK2V617F burden. In PV patients the JAK2 burden and Hb levels correlated with occurrence of pruritus. Our study seems to point out a possible involvement of IL-23 in the pathogenesis of PV.

• Authors: Sebastiano Gangemi, Alessandro Allegra, Elisabetta Pace, Andrea Alonci, Maria Ferraro, Annamaria Petrungaro, Salvatore Saitta, Demetrio Gerace, Sabina Russo, Giuseppa Penna, Caterina Musolino
• Journal: Cellular immunology (Cell Immunol) 2012 Jul-Aug Vol. 278 Issue 1-2 Pg. 91-4 ISSN: 1090-2163 [Electronic] Netherlands
• PMID: 23121980 (Publication Type: Journal Article)
• Copyright: Copyright © 2012. Published by Elsevier Inc.

Chemical References

• Hemoglobins
• IL10 protein, human
• Interleukin-23
• Interleukins
• Interleukin-10
• JAK2 protein, human
• Janus Kinase 2

Topics

• Aged
• Female
• Hemoglobins (analysis, immunology)
• Humans
• Interleukin-10 (blood, genetics, immunology)
• Interleukin-23 (blood, genetics, immunology)
• Interleukins (blood, genetics, immunology)
• Janus Kinase 2 (blood, genetics, immunology)
• Male
• Middle Aged
• Mutation
• Polycythemia Vera (blood, complications, genetics, immunology)
• Pruritus (blood, genetics, immunology)
• Thrombocythemia, Essential (blood, complications, genetics, immunology)
• Thrombosis (blood, genetics, immunology)
• Interleukin-22