Laboratory
infarction diagnostics are based on the detection of elevated serum activities of
creatine kinase (CK)
Creatine kinase Isoenzyme MB (CKMB) and
Transaminases. Determination of these cardiac marker
enzymes permits the diagnosis of transmural
myocardial infarction. However in such patients the diagnosis of acute
myocardial infarction can be confirmed by the clinical symptoms and changes in the ECG, in addition to the
enzyme assays. The 50 AMI patients selected in the present study were those admitted to the ICCU of Shri Krishna Hospital, Karamsad. The blood samples were taken at Zero hours (i.e. at the time of admission of the patient). Within 6 hrs of the starting of
chest pain, 1.5 million units of
streptokinase were mixed with 100 to 150ml of
normal saline and administered by infusion over a period of one hour. The blood samples were further collected at intervals of 6 hrs, 14hrs, 32hrs, 48hrs, 5(th) day and 7(th) day. The blood samples were analyzed for CK, CKMB,
SGOT, α HBDH and Cardiac specific
Troponin T. By 6hrs the CK and CKMB values had started rising, the rise continuing at 14hrs with peak values at 32hrs. The CK showed a slight decrease by 48 hrs. The cardiac
Troponin T showed wide time window from 4 hrs to 7(th) day for detecting myocardial damage. The maximum cardiac
Troponin T values were during the first 24hrs. Cardiac
Troponin T in serum appears to be a more sensitive and early
indicator of myocardial cell injury in comparison to CKMB.