Troponin T (T, Troponin)

One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

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Networked: 2125 relevant articles (49 outcomes, 308 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Katus, Hugo A: 41 articles (11/2015 - 01/2002)
2.	Giannitsis, Evangelos: 37 articles (11/2015 - 01/2002)
3.	Jaffe, Allan S: 23 articles (11/2015 - 06/2004)
4.	Januzzi, James L: 23 articles (04/2015 - 12/2002)
5.	Ballantyne, Christie M: 22 articles (09/2015 - 04/2011)
6.	Mueller, Christian: 20 articles (12/2015 - 12/2004)
7.	Twerenbold, Raphael: 19 articles (12/2015 - 05/2011)
8.	Reichlin, Tobias: 19 articles (12/2015 - 05/2011)
9.	Lindahl, Bertil: 19 articles (08/2014 - 05/2002)
10.	Haaf, Philip: 17 articles (05/2015 - 05/2011)

Related Diseases

1.	Myocardial Infarction 03/01/2012 - "High-sensitivity cardiac troponin T (cTnT) assays detect small clinically important myocardial infarctions (MI) but also yield higher rates of false-positive results owing to increased concentrations sometimes present in patients without MI. " 06/01/2013 - "To determine if an algorithm implementing a serial high-sensitive cardiac troponin T (hs-cTnT) measurement at presentation (0 h) and at 3 hours after presentation (3h) is helpful for early diagnosis of non-ST-elevation myocardial infarction (NSTEMI) in older patients. " 10/01/2002 - "Prognostic significance of admission cardiac troponin T in patients treated successfully with direct percutaneous interventions for acute ST-segment elevation myocardial infarction." 10/01/2002 - "Troponin T is an early indicator of myocardial infarction and is superior to CKMB in diagnosis of myocardial injury. " 08/18/2001 - "Performance of the diagnostic test against a gold standard consisting of either a 48 hour measurement of troponin T concentration or screening for myocardial infarction according to the World Health Organization's criteria. "
2.	Acute Coronary Syndrome 05/01/2001 - "The diagnostic efficacy of the rapid troponin T test was remarkable in patients with the non-ST elevation type of acute coronary syndrome. " 07/01/2011 - "Improved diagnostic and prognostic performance of a new high-sensitive troponin T assay in patients with acute coronary syndrome." 04/01/2011 - "A third troponin T blood sample is not cost-effective in patients with suspected non-ST segment elevation acute coronary syndrome." 06/30/1999 - "Analysis of cardiac troponin T and I have been shown to be effective in detecting minor myocardial injury in cardiac patients who present with acute coronary syndromes (ACS). " 06/01/2000 - "Of the 26 patients who were ultimately diagnosed as having acute coronary syndrome, seven patients (27%) had positive cardiac troponin T assay results, whereas none of the patients without acute coronary syndrome had positive results (0%). "
3.	Chest Pain (Chest Pains) 01/01/2009 - "Thus, the combination of H-FABP and IMA measurements after initiation of chest pain may be highly effective for risk stratification in patients with ACS and normal cardiac troponin T." 01/15/2016 - "Recent studies have indicated that it may be safe to discharge chest pain patients with an initial high-sensitivity cardiac troponin T (hs-cTnT) level of <5ng/L from the emergency department (ED) without further evaluation. " 08/01/2013 - "The goal of our study is to compare negative predictive value of the algorithm in the chest pain unit using the fourth-generation troponin T assay (4GTT) vs high-sensitivity troponin T assay (HSTT). " 01/01/2013 - "The goal of this study was to determine the ability of a single, resting high-sensitivity troponin T (hsTnT) measurement to predict abnormal myocardial perfusion imaging (MPI) in patients presenting with acute chest pain to the emergency department (ED). " 01/01/2012 - "This study was aimed at assessing the bias of high sensitive cardiac troponin T vs. the standard cardiac troponin T in a selected population with chest pain of presumed cardiac origin. "
4.	Unstable Angina 09/15/1998 - "Thus, in patients with class IIIB unstable angina, among data potentially available on admission, serum levels of troponin T and CRP have a significantly greater prognostic accuracy than symptoms and ECGs. " 02/01/1999 - "The aim of this study was to compare the prognostic efficacy of cardiac troponin T (cTnT) and I (cTnI) in patients with clinical unstable angina. " 06/01/2001 - "To study the angiographic correlates of cardiac troponin T (cTnT)-positive and -negative patients with unstable angina pectoris. " 11/01/2000 - "To examine the prognostic significance of Troponin-T in patients admitted with unstable angina and to study their angiographic morphology. " 11/01/2000 - "Troponin-T in unstable angina--a clinical and angiographic study."
5.	Necrosis 06/23/2015 - "In HFDYS patients, miR-30d plasma levels inversely correlated with high-sensitivity troponin T, a marker of myocardial necrosis. " 01/24/2014 - "Post-procedural myocardial necrosis manifested by elevated cardiac troponin T (cTnT) often complicates percutaneous coronary intervention (PCI). " 10/15/2013 - "C1r and C3 were increased in the early phase with a subsequent decrease 3 days after, being C1r levels at admission correlated with necrosis and troponin-T and GPT levels. " 08/01/2013 - "With CQ, IH for 4weeks increased serum troponin T levels, reflecting necrosis. " 01/01/2013 - "Troponin T was elevated but other markers of myocardial necrosis were negative, as was coronary angiography. "

Related Drugs and Biologics

1.	Trinitrotoluene (TNT)
2.	Biological Markers (Surrogate Marker)
3.	Troponin I
4.	Brain Natriuretic Peptide (Natrecor)
5.	pro-brain natriuretic peptide (1-76)
6.	MB Form Creatine Kinase
7.	Myoglobin
8.	Enzymes
9.	Proteins (Proteins, Gene)
10.	abciximab (ReoPro)

Related Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
2.	Aftercare (After-Treatment)
3.	Intensive Care (Surgical Intensive Care)
4.	Amputation
5.	Renal Dialysis (Hemodialysis)