Screening of polyphenolic plant extracts for anti-obesity properties in Wistar rats.

Abstract

BACKGROUND:

Polyphenols have been reported to prevent chronic diseases such as cardiovascular diseases, cancers, diabetes and neurodegenerative diseases. The objective of the study was to conduct a screening for potential anti-obesity polyphenolic plant extracts using a diet-induced animal model. Rats were fed a high-fat-sucrose (HFS) diet with or without supplementation of different polyphenolic plant extracts (almond, apple, cinnamon, orange blossom, hamamelis, lime blossom, grape vine, and birch) for 56-64 days.

RESULTS:

Body weight gain was lower in rats supplemented with apple, cinnamon, hamamelis and birch extracts as compared to HFS non-supplemented group. Moreover, apple and cinnamon extracts prevented the increase in fat mass promoted by the HFS diet. Insulin resistance, estimated by the homostatic model assessment-insulin resistance (HOMA-IR) index, was reduced in rats fed apple, cinnamon, hamamelis and birch extracts. Apple extract also prevented the HFS-induced hyperglycaemia and hyperleptinaemia.

CONCLUSION:

Only apple and cinnamon extracts were finally considered as potentially important anti-obesogenic extracts, due to their body fat-lowering effects, while the improvement of obesity-related metabolic complications by apple polyphenols highlights this extract as a promising functional food ingredient for the management of obesity and its metabolic complications.

• Authors: Noemi Boqué, Javier Campión, Rocío de la Iglesia, Ana L de la Garza, Fermín I Milagro, Belén San Román, Óscar Bañuelos, J Alfredo Martínez
• Journal: Journal of the science of food and agriculture (J Sci Food Agric) Vol. 93 Issue 5 Pg. 1226-32 (Mar 30 2013) ISSN: 1097-0010 [Electronic] England
• PMID: 23080265 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 Society of Chemical Industry.

Chemical References

• Anti-Obesity Agents
• Antioxidants
• Dietary Sucrose
• Leptin
• Plant Extracts
• Polyphenols

Topics

• Adipose Tissue, White (metabolism, pathology)
• Adiposity
• Animals
• Anti-Obesity Agents (analysis, chemistry, therapeutic use)
• Antioxidants (analysis, therapeutic use)
• Cinnamomum zeylanicum (chemistry)
• Dietary Sucrose (adverse effects)
• Dietary Supplements (analysis)
• Fruit (chemistry)
• Hyperglycemia (etiology, prevention & control)
• Insulin Resistance
• Leptin (blood)
• Male
• Malus (chemistry)
• Obesity (etiology, metabolism, pathology, prevention & control)
• Plant Bark (chemistry)
• Plant Extracts (chemistry, therapeutic use)
• Polyphenols (analysis, therapeutic use)
• Random Allocation
• Rats
• Rats, Wistar
• Weight Gain